32493-80-4

Basic information

• Product Name: 2,3-dichloro-5-phenylpyrazine
• CAS NO: 32493-80-4
• Molecular Formula: C₁₀H₆Cl₂N₂
• Molecular Weight: 225.074
• Mol File: 32493-80-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 321.6°C at 760 mmHg
• Flash Point: 177.9°C
• Density: 1.363g/cm³
• Vapor Pressure: 0.000553mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2,3-dichloro-5-phenylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dichloro-5-phenylpyrazine(32493-80-4)
• EPA Substance Registry System: 2,3-dichloro-5-phenylpyrazine(32493-80-4)

Safety Data

• Hazardous Substances Data: 32493-80-4(Hazardous Substances Data)

Usage

General Description

2,3-dichloro-5-phenylpyrazine is a chemical compound with the molecular formula C10H6Cl2N2. It is a pyrazine derivative that contains two chlorine atoms and a phenyl group attached to the pyrazine ring. 2,3-dichloro-5-phenylpyrazine is a white to yellow crystalline solid that is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the preparation of complex organic molecules. 2,3-dichloro-5-phenylpyrazine has been found to exhibit insecticidal activity and has potential applications in the field of pesticide development. Additionally, it has been studied for its pharmacological properties and may have potential therapeutic uses. Overall, this compound has a variety of industrial and scientific applications due to its unique chemical structure and properties.

Upstream product

• 60-29-7 diethyl ether 
• 75-87-6 chloral 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 66769-60-6 3-chloro-5-phenylpyrazine 1-oxide 
• 61578-11-8 2-chloro-5-phenylpyrazine-1-oxide 
• 243472-80-2 2-phenyl-5-trimethylsilanyloxy-pyrazine 
• 1074-12-0 phenylglyoxal hydrate 
• 29460-97-7 2-phenylpyrazine 
• 25844-73-9 2-Chloro-5-phenyl-pyrazine 
• 41270-62-6 2-chloro-6-phenylpyrazine 
• 58861-87-3 2-chloro-3-phenyl-pyrazine 4-oxide 
• 4858-85-9 2,3-dichloropyrazine 
• 98-80-6 phenylboronic acid 
• 67602-02-2 3-bromo-5-phenyl-1H-pyrazin-2-one 

Relevant articles and documents

Iron-catalyzed direct C-H arylation of heterocycles and quinones with arylboronic acids

The arylation of C-H bonds to generate heteroaryl-aryl (Het-Ar) and arylated quinone (Quin-Ar) compounds has received great attention to achieve sustainable goals in synthetic chemistry. Despite significant advances, arylation of a broad range of Het-Ar and Quin-Ar derivatives remains a challenging task. Herein, a variety of heterocycles are arylated by using arylboronic acids in the presence of catalytic amounts of inexpensive Fe(NO 3)3. The C-arylated quinone compounds can be prepared by reacting arylboronic acids with either quinone or hydroquinone. The present method is operationally simple, scalable, does not require prefunctionalization of the heterocycle or quinone, and can tolerate a wide variety of functional groups in the coupling partners. These qualities are expected to render this method attractive for academic and industrial use. Direct C-H arylation of a variety of heterocycles and quinones with arylboronic acids has been developed. An inexpensive iron catalyst, Fe(NO3)3, and a co-oxidant, persulfate, were used in air. The protocol is applicable for large-scale synthesis and is expected to find application as a result of its operational simplicity. Copyright

Studies on pyrazines. 35 [1]. An improved synthesis of bromopyrazines from hydroxypyrazines

The synthesis of bromopyrazines from hydroxypyrazines was successfully effected by the procedure via trimethylsilyloxypyrazines, the sequence of which proceeds under mild conditions and does not require the isolation of intermediate.

Some Reactions of Mono Substituted Pyrazine Monoxides

The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated.Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred