32493-80-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-dichloro-5-phenylpyrazine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic uses.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,3-dichloro-5-phenylpyrazine is utilized as a building block in the preparation of complex organic molecules, which can be further used in the creation of pesticides and other agrochemicals.
Used in Insecticide Development:
2,3-dichloro-5-phenylpyrazine is used as an active ingredient in the development of insecticides due to its insecticidal activity, making it a valuable component in pest control strategies.
Used in Scientific Research:
2,3-dichloro-5-phenylpyrazine is also used in scientific research for studying its pharmacological properties, which may lead to the discovery of new therapeutic applications and a better understanding of its potential impact on various biological systems.

Upstream product

• 60-29-7 diethyl ether 
• 75-87-6 chloral 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 66769-60-6 3-chloro-5-phenylpyrazine 1-oxide 
• 61578-11-8 2-chloro-5-phenylpyrazine-1-oxide 
• 41270-65-9 2-chloro-3-phenylpyrazine 
• 1074-12-0 phenylglyoxal hydrate 
• 160315-13-9 2-acetoxy-5-phenylpyrazine 
• 160315-17-3 2-acetoxy-6-phenylpyrazine 
• 160315-09-3 2-acetoxy-3-phenylpyrazine 
• 29460-97-7 2-phenylpyrazine 
• 2882-18-0 2-hydroxy-3-phenylpyrazine 
• 41270-59-1 6-phenyl-1H-pyrazin-2-one 
• 58861-89-5 2-phenylpyrazine N⁽¹⁾-oxide 

Relevant academic research and scientific papers

Iron-catalyzed direct C-H arylation of heterocycles and quinones with arylboronic acids

The arylation of C-H bonds to generate heteroaryl-aryl (Het-Ar) and arylated quinone (Quin-Ar) compounds has received great attention to achieve sustainable goals in synthetic chemistry. Despite significant advances, arylation of a broad range of Het-Ar and Quin-Ar derivatives remains a challenging task. Herein, a variety of heterocycles are arylated by using arylboronic acids in the presence of catalytic amounts of inexpensive Fe(NO 3)3. The C-arylated quinone compounds can be prepared by reacting arylboronic acids with either quinone or hydroquinone. The present method is operationally simple, scalable, does not require prefunctionalization of the heterocycle or quinone, and can tolerate a wide variety of functional groups in the coupling partners. These qualities are expected to render this method attractive for academic and industrial use. Direct C-H arylation of a variety of heterocycles and quinones with arylboronic acids has been developed. An inexpensive iron catalyst, Fe(NO3)3, and a co-oxidant, persulfate, were used in air. The protocol is applicable for large-scale synthesis and is expected to find application as a result of its operational simplicity. Copyright

SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS

The invention relates to compounds of formula (I) prodrugs thereof, and the pahrmaceutically acceptabel salts of the compounds and prodrugs, wherein Ra, Rb, R1 and R2 are as defined herein; pharmaceutical compositions thereof; and uses thereof.

Studies on pyrazines. 35 [1]. An improved synthesis of bromopyrazines from hydroxypyrazines

The synthesis of bromopyrazines from hydroxypyrazines was successfully effected by the procedure via trimethylsilyloxypyrazines, the sequence of which proceeds under mild conditions and does not require the isolation of intermediate.

Some Reactions of Mono Substituted Pyrazine Monoxides

The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated.Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred