2,3-Dichloro-5-phenylpyrazine

Base Information

• Chemical Name: 2,3-Dichloro-5-phenylpyrazine
• CAS No.: 32493-80-4
• Molecular Formula: C10H6Cl2N2
• Molecular Weight: 225.074
• NSC Number: 129583
• DSSTox Substance ID: DTXSID20299353
• Nikkaji Number: J1.175.416C
• Wikidata: Q82041705
• Mol file: 32493-80-4.mol

Synonyms:2,3-dichloro-5-phenylpyrazine;32493-80-4;NSC 129583;NSC129583;SCHEMBL3525387;DTXSID20299353;NSC-129583

Chemical Property of 2,3-Dichloro-5-phenylpyrazine

Chemical Property:

• Vapor Pressure: 0.000553mmHg at 25°C
• Boiling Point: 321.6°Cat760mmHg
• Flash Point: 177.9°C
• Density: 1.363g/cm³
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.9908036
• Heavy Atom Count: 14
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(C(=N2)Cl)Cl

Technology Process of 2,3-Dichloro-5-phenylpyrazine

There total 24 articles about 2,3-Dichloro-5-phenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,3-dichloropyrazine (4858-85-9) + phenylboronic acid (98-80-6) → 2,3-dichloro-5-phenylpyrazine (32493-80-4)

Guidance literature:

2,3-dichloropyrazine; With Iron(III) nitrate nonahydrate; dipotassium peroxodisulfate; trifluoroacetic acid; In water; at 20 ℃; for 0.166667h; Schlenk technique;

phenylboronic acid; In water; at 70 ℃; for 24h; Schlenk technique;

DOI:10.1002/ejoc.201300743

Reference yield: 42.0%

3-chloro-5-phenylpyrazine 1-oxide (66769-60-6) → 2,3-dichloro-5-phenylpyrazine (32493-80-4) + 2,5-dichloro-6-phenylpyrazine (64163-09-3)

Guidance literature:

With trichlorophosphate; for 0.5h; Yields of byproduct given; Heating;

Reference yield:

3-bromo-5-phenyl-1H-pyrazin-2-one (67602-02-2) + trichlorophosphate (10025-87-3,12599-09-6,63736-95-8,39380-77-3) → 2,3-dichloro-5-phenylpyrazine (32493-80-4)

Guidance literature:

3-bromo-5-phenyl-1H-pyrazin-2-one; trichlorophosphate; for 4h; Heating / reflux;

With sodium hydroxide; In water;

upstream raw materials:

diethyl ether

chloral

2-amino-2-phenylacetonitrile

3-chloro-5-phenylpyrazine 1-oxide

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