32497-10-2

Usage

Uses

Used in Pharmaceutical Industry:
4-METHYL-1,3-THIAZOL-2(3H)-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications. Its unique structure allows for the creation of molecules with specific biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-METHYL-1,3-THIAZOL-2(3H)-ONE is utilized as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Organic Synthesis:
4-METHYL-1,3-THIAZOL-2(3H)-ONE is employed as a versatile building block in organic synthesis, allowing for the creation of a wide range of organic compounds with diverse applications. Its reactivity and structural features make it a preferred choice for chemists working on the development of new organic molecules for various industries.
Used in Antimicrobial and Anti-Fungal Applications:
4-METHYL-1,3-THIAZOL-2(3H)-ONE has been studied for its potential antimicrobial and antifungal properties, making it a candidate for use in applications where control of microbial growth is necessary. This includes uses in healthcare settings, food preservation, and other industries where preventing the spread of microorganisms is crucial.

InChI:InChI=1/C4H5NOS/c1-3-2-7-4(6)5-3/h2H,1H3,(H,5,6)

Upstream product

• 3029-48-9 thiocyanoacetone 
• 683-63-6 O-methyl thiocarbamate 
• 78-95-5 chloroacetone 
• 625-57-0 O-ethyl thiocarbamate 
• 333-20-0 potassium thioacyanate 
• 598-31-2 1-bromoacetone 
• 16687-42-6 ammonium thiocarbamate 
• 475645-27-3 2-ethoxy-4-methyl-thiazole 

Downstream Products

• 693-95-8 4-Methylthiazole 
• 26847-01-8 2-chloro-4-methyl-1,3-thiazole 
• 32497-14-6 5-acetyl-4-methylthiazol-2(3H)-one 
• 115879-63-5 4-methyl-3-(2-pyridylmethyl)thiazol-2(3H)-one 
• 90916-46-4 (4-methyl-thiazol-2-yl)-phenyl-amine 
• 4288-20-4 N,N'-bis-(4-methyl-thiazol-2-yl)-m-phenylenediamine 
• 100061-42-5 (4-methyl-thiazol-2-yl)-p-tolyl-amine 
• 533885-96-0 4-methyl-2-oxo-2,3-dihydro-thiazole-5-carbaldehyde 
• 533886-13-4 4-methyl-5-(4-nitro-phenylsulfanyl)-3H-thiazol-2-one 

Relevant academic research and scientific papers

Synthesis of thiaazaheterocycle nucleoside analogues

The syntheses of thiazinone, thiazinedione and thiazolinone base modified nucleoside analogues have been discussed in both the deoxy- and ribosyl series. Both inter- and intramolecular N-glycosylations were evaluated.

Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles

(Matrix presented) This paper describes Sonogashira cross-coupling of functionalized 2-, 4-, and 5-trifloyl oxazoles and thiazoles with terminal alkynes. This methodology has been extended to 2,4-ditrifloylthiazoles, which results in regioselective cross-coupling at the C2-position of the thiazole. The resulting 2-alkynyl-4-trifloylthiazoles are effective electrophiles in a second palladium(0)-mediated cross-coupling reaction.

Flavouring a foodstuff with compounds containing a sulphur atom linked to two specific atoms or groups

The invention relates to a process for flavouring foodstuffs by incorporating therein an effective amount of at least one compound R1-S-R2 with a specific, well defined structure such as (E)-2-methyl-1-(methylthio)-2-butene; S-ethyl thioformate; S-ethyl-2-(acetylamino)thioacetate; N-(2-methylthioethyl)acetamide; methyl-2-mercaptopropionate; propyl-2-mercaptopropionate; 2-(isopropylthio)pentane; 2-propenylthiol; 4-methyl-2-3H-thiazolone or tautomer; and 2,3-dimethyl-4-formylthiophene. The invention also covers a foodstuff and/or a flavouring concentrate containing at least one of the above identified compounds.

Synthesis of Heterocyclic Compounds from 0-Aminobenzenethiol and Ammonium Thiocarbamate

The reaction of o-aminobenzenethiol with carbonyl sulfide in the presence of triethylamine afforded an alternate route for the synthesis of 2-benzothiazolinone (1) in 97-98percent yield.The reaction of ammonium thiocarbamate (2) with 2-chlorocyclohexanone furnished the novel 4,5,6,7-tetrahydro-2-benzothiazolinone (3). 3-Ethoxy-2H-1,4-benzothiazin-2-one (7) was prepared by the reaction of o-aminobenzenethiol with diethyl oxalate.Possible pathways and supporting nmr, ir and mass spectra are discussed.