325166-93-6Relevant articles and documents
Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex
Van, Hue Thi My,Le, Quynh Manh,Lee, Kwang Youl,Lee, Eung-Seok,Kwon, Youngjoo,Kim, Tae Sung,Le, Thanh Nguyen,Lee, Suh-Hee,Cho, Won-Jea
, p. 5763 - 5767 (2007)
11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxici
Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors
Cho, Won-Jea,Le, Quynh Manh,My Van, Hue Thi,Youl Lee, Kwang,Kang, Bok Yun,Lee, Eung-Seok,Lee, Sang Kook,Kwon, Youngjoo
, p. 3531 - 3534 (2008/02/07)
An intramolecular radical cyclization reaction of 4-bromo-3-arylisoquinolines 11a-c allowed the efficient synthesis of 11-methylindenoisoquinolines 2a-c. 5-(2-Aminoethylamino)indeno[1,2-c]isoquinolin-11-one 4 was also prepared in the convenient manner. Th