32563-24-9

Basic information

• Product Name: L-ERYTHRO-4-FLUOROGLUTAMIC ACID
• Synonyms: L-ERYTHRO-4-FLUOROGLUTAMIC ACID;L-ERYTHRO-4-FLUOROGLUTAMIC ACID 99%;L-erythro-4-Fluoroglutamic acid 99.9%
• CAS NO: 32563-24-9
• Molecular Formula: C₅H₈FNO₄
• Molecular Weight: 165.12
• Mol File: 32563-24-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 179-180
• Boiling Point: 342.4°C at 760 mmHg
• Flash Point: 160.9°C
• Appearance: /
• Density: 1.498g/cm³
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: L-ERYTHRO-4-FLUOROGLUTAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: L-ERYTHRO-4-FLUOROGLUTAMIC ACID(32563-24-9)
• EPA Substance Registry System: L-ERYTHRO-4-FLUOROGLUTAMIC ACID(32563-24-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 32563-24-9(Hazardous Substances Data)

Usage

General Description

L-ERYTHRO-4-FLUOROGLUTAMIC ACID is a synthetic compound that belongs to the family of amino acids. It is derived from glutamic acid, an important neurotransmitter in the central nervous system. L-ERYTHRO-4-FLUOROGLUTAMIC ACID is characterized by the presence of a fluorine atom on the 4th position of the glutamic acid molecule. Due to its specific chemical structure, L-ERYTHRO-4-FLUOROGLUTAMIC ACID has been studied for its potential use in the development of pharmaceutical drugs, particularly in the field of neurological disorders and psychiatric conditions. Its unique properties make it a valuable tool for researchers in the study of glutamate receptors and their role in various physiological and pathological processes.

InChI:InChI=1/C5H8FNO4/c6-2(4(8)9)1-3(7)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)/t2-,3-/m0/s1

Upstream product

• 13504-86-4 (2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 51-35-4 4R-4-hydroxyproline 
• 618-27-9 hydroxy L-proline 
• 2708-77-2 D,L-erythro,threo-4-fluoroglutamic acid 
• 67943-19-5 methyl (2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylate 
• 132651-95-7 N-acetyl-4(R)-fluoro-L-proline methyl ester 
• 78804-96-3 (2S,4S)-1-acetyl-4-hydroxyproline methyl ester 
• 2358-03-4 erythro-4-fluoroglutamic acid 5-methyl ester 
• 393810-25-8 (2S,4R)-4-fluoro-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 91307-56-1 L-leucyl-L-erythro-γ-fluoroglutamate 
• 91307-51-6 L-leucyl-D,L-(threo+erythro)-γ-fluoroglutamate 
• 149033-38-5 Methyl 1-acetyl-trans-4-fluoro-D-pyrrolidin-5-one-2-carboxylate 

Relevant articles and documents

[F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamine, derivatives thereof and use thereof and processes for their preparation

The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION

The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.

Practical synthesis of L-erythro- and L-threo-4-fluoroglutamic acids using aminoacylase

Enantiomerically pure L-erythro- and L-threo-4-fluoroglutamic acids 1a and 1b were conveniently prepared. The key steps in this synthesis relied upon separation of diastereomers of N-chloroacetyl-4-fluoroglutamic acid 5-methyl ester 7 by recrystallization and enzymatic resolution of enantiomers of the resulting 7(a+c) and 7(b+d) by aminoacylase. Protection of the γ-carboxyl group as a methyl ester was found to be crucial for this enzymatic reaction.