32566-86-2

Upstream product

• 119-61-9 benzophenone 
• 134-32-7 1-amino-naphthalene 
• 2051-90-3 Dichlorodiphenylmethane 
• 1013-88-3 Benzophenone imine 
• 99747-74-7 1-naphthyl triflate 
• 36773-67-8 1-naphthoic acid,phenyl ester 
• 90-15-3 α-naphthol 
• 74734-13-7 naphthalen-8-yl pivalate 
• 90-13-1 1-Chloronaphthalene 

Downstream Products

• 67241-10-5 N-α-Naphthyl-α-chloro-α,α-diphenylacetimidoylchlorid 
• 119-61-9 benzophenone 
• 134-32-7 1-amino-naphthalene 
• 112685-96-8 N-benzhydrylnaphthalen-1-amine 
• 73567-89-2 Dimethyl meso-3,3-Diphenylcyclopropane-1,2-dicarboxylate 
• 73567-88-1 (+/-)-(R,R)-dimethyl 3,3-diphenylcyclopropane-1,2-dicarboxylate 

Relevant academic research and scientific papers

Cyclopalladated benzophenone imines: Synthesis, antitumor activity, cell accumulation, dna interaction, and cathepsin b inhibition

The synthesis of the endo five-membered cyclo-ortho-palladated benzophenone imines [Pd{C6H4(Ph)C=NR}]2(μ-X)2 [1 (X = OAc), 2 (X = Cl), a (R = phenyl), b (R = 1-naphthyl), c (R = benzyl), d (R = α-methylbenzyl)], and trans-N,P-[Pd{C6H4(Ph)C=NR}X(PPh3)] [3 (X = OAc), 4 (X = Cl), a (R = phenyl), b (R = 1-naphthyl), c (R = benzyl), d (R = α-methylbenzyl)] and the X-ray molecular structure of 1a, 1c, 1d, 4a, 4b, and 4c are reported. The antitumor activity, DNA interaction, and cathepsin B inhibition of palladium compounds a-d were studied and compared with those previously reported for palladium compounds e with R = H and compound 4f analogous to 4e but with a platinum(II) center. The IC50 values against a panel of human cancer cell lines allowed the establishment of a qualitative relationship between their structure and antitumor activity. Compounds 3e, 4e, and 4f were the most active ones in relation to their in vitro anticancer activity. Compounds 3e and 4e were about 4 times more active than cisplatin against the MDA-MB-231 and MCF-7 breast human cancer lines, and compound 4f was about 4 times more active than cisplatin against the cisplatin-resistant HCT-116 colon human cancer cell line. In addition, compound 3e was 3 times less cytotoxic than cisplatin toward the quiescent HUVEC cells. Accumulation of palladium compounds e and b in the MDA-MB-231 cell line was considerably greater than that of cisplatin in the same cell line, but palladium compounds b were noncytotoxic. Some of these complexes altered the DNA tertiary structure in a similar way to cisplatin but at higher concentration, and most cytotoxic ones did not present a high efficiency as cathepsin B inhibitors.

Catalytic Ester and Amide to Amine Interconversion: Nickel-Catalyzed Decarbonylative Amination of Esters and Amides by C?O and C?C Bond Activation

An efficient nickel-catalyzed decarbonylative amination reaction of aryl and heteroaryl esters has been achieved for the first time. The new amination protocol allows the direct interconversion of esters and amides into the corresponding amines and represents a good alternative to classical rearrangements as well as cross coupling reactions.

Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C-O Bond Cleavage

A nickel-catalyzed protocol for the conversion of aryl and heteroaryl alcohol derivatives to primary and secondary aromatic amines via C(sp2)-O bond cleavage is described. The new amination protocol can be applied to a range of substrates bearing diverse functional groups and uses readily available benzophenone imines as an effective nitrogen source.

Facile synthesis of triarylmethanimine promoted by a lewis acidbase pair: Theoretical and experimental studies

An efficient method for triarylmethanimine synthesis promoted by a Lewis acidbase pair (AlCl3Et3N) was designed using mechanistic analysis with the aid of density functional theory. A series of triarylmethanimines were successfully prepared under mild con

Trans-spanned palladium catalyst for mild and efficient amination of aryl halides with benzophenone imine

A new protocol for palladium-catalyzed Buchwald-Hartwig amination of aryl chlorides and bromides with benzophenone imine as ammonia surrogate is described. The suggested reaction conditions are mild and may therefore be applied to a variety of sensitive starting materials. Georg Thieme Verlag Stuttgart.

An ammonia equivalent for the palladium-catalyzed amination of aryl halides and triflates

Commercially available benzophenone imine serves as a convenient ammonia equivalent in the palladium-catalyzed amination of aryl halides and triflates. The benzophenone imine adducts can be cleaved directly to the corresponding primary anilines by catalytic hydrogenation or treatment with hydroxylamine hydrochloride or a catalytic amount of HCl in wet THF.

AZIRIDINES FROM SCHIFF BASES WITH CARBENES. NEW METHODS IN THE GENERATION OF METHYLENE AND DIPHENYLCARBENE

The formation of dichloroaziridines from azomethines (Schiff bases) and dichlorocarbene depends upon the structure of the Schiff base and the procedure adopted in the generation of dichlorocarbene. Azomethines derived from aromatic aldehydes and aromatic