99747-74-7

Basic information

• Product Name: 1-NAPHTHYL TRIFLATE
• Synonyms: AIDS143027;1-NAPHTHYL TRIFLATE;1-NAPHTHYL TRIFLUOROMETHANESULFONATE
• CAS NO: 99747-74-7
• Molecular Formula: C₁₁H₇F₃O₃S
• Molecular Weight: 276.23
• Product Categories: Building Blocks;Chemical Synthesis;Organic Building Blocks;Organic Triflates;Sulfur Compounds
• Mol File: 99747-74-7.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 97-98 °C0.3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Colorless dark red/Liquid
• Density: 1.405 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000137mmHg at 25°C
• Refractive Index: n20/D 1.52(lit.)
• CAS DataBase Reference: 1-NAPHTHYL TRIFLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-NAPHTHYL TRIFLATE(99747-74-7)
• EPA Substance Registry System: 1-NAPHTHYL TRIFLATE(99747-74-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 99747-74-7(Hazardous Substances Data)

Usage

General Description

1-Naphthyl triflate is a chemical compound with the formula C11H7F3O3S that is commonly used as a reagent in organic synthesis. It is a triflate ester derivative of 1-naphthol and is often utilized as a mild electrophile in various reactions, such as cross-coupling reactions and nucleophilic aromatic substitution. 1-Naphthyl triflate is known for its ability to facilitate the transfer of the naphthyl group to nucleophiles, making it a valuable tool in the preparation of various functionalized naphthalene derivatives. The compound is regarded as a versatile and reliable reagent in organic synthesis, finding applications in the pharmaceutical, agrochemical, and materials science industries. Due to its useful synthetic applications, 1-naphthyl triflate is a well-studied and widely utilized compound in the field of organic chemistry.

InChI:InChI=1/C11H7F3O3S/c12-11(13,14)18(15,16)17-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H

Upstream product

• 421-83-0 trifluoromethane sulfonyl chloride 
• 90-15-3 α-naphthol 
• 17763-80-3 para-nitrophenyl triflate 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 91-20-3 naphthalene 
• 141171-91-7 1-<1-(1-naphthyl)ethenyl>succinimide 
• 141171-97-3 (E)-1-<2-(1-naphthyl)ethenyl>succinimide 
• 3506-84-1 4-(1-naphthyl)-2-butanone 
• 141171-89-3 3-(naphthalen-1-yl)but-3-en-2-ol 
• 941-98-0 1'-naphthacetophenone 
• 127087-65-4 (Z)-1-(2-butoxyethenyl)naphthalene 
• 127087-64-3 (E)-1-(2-butoxyethenyl)naphthalene 
• 127931-52-6 2-(2-(1-naphthyl)-2-oxoethyl)cyclohexanone 
• 605-02-7 1-phenylnaphthalene 
• 826-74-4 1-vinylnaphthalene 
• 32566-86-2 benzhydrylidene-[1]naphthyl-amine 
• 86-55-5 1-naphthalenecarboxylic acid 
• 65490-21-3 1-(phenylselanyl)naphthalene 

Relevant articles and documents

Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

Pd-Catalyzed Intermolecular Transthiolation of Ar-OTf Using Methyl 3-(Methylthio) Propanoate as a Thiol Surrogate

A method for the odorless synthesis of unsymmetrical sulfides via Csp2?O and Csp3?S bond activation is presented. Using methyl 3-(methylthio) propanoate as a MeSH surrogate, a series of substituted aryl methyl sulfides have been obtained in moderate to good yields. This catalytic protocol can also tolerate methyl 3-(methylthio)propionate derivatives to afford the corresponding aryl sulfides.

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.