99747-74-7

Usage

Uses

Used in Organic Synthesis:
1-NAPHTHYL TRIFLATE is used as a reagent for facilitating the transfer of the naphthyl group to nucleophiles in various reactions, such as cross-coupling reactions and nucleophilic aromatic substitution.
Used in Pharmaceutical Industry:
1-NAPHTHYL TRIFLATE is used as a reagent for the preparation of functionalized naphthalene derivatives, which are valuable in the development of pharmaceutical compounds.
Used in Agrochemical Industry:
1-NAPHTHYL TRIFLATE is used as a reagent for the synthesis of naphthalene-based agrochemicals, contributing to the development of effective crop protection agents.
Used in Materials Science:
1-NAPHTHYL TRIFLATE is used as a reagent for the synthesis of naphthalene-based materials, which can be utilized in various applications within the materials science field.

InChI:InChI=1/C11H7F3O3S/c12-11(13,14)18(15,16)17-10-7-3-5-8-4-1-2-6-9(8)10/h1-7H

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 90-15-3 α-naphthol 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 17763-80-3 para-nitrophenyl triflate 

Downstream Products

• 28358-65-8 1-(1-naphthyl)styrene 
• 2840-87-1 (E)-1-styrylnaphthalene 
• 2840-87-1 1-styrylnaphthalene 
• 91-20-3 naphthalene 
• 141171-91-7 1-<1-(1-naphthyl)ethenyl>succinimide 
• 141171-97-3 (E)-1-<2-(1-naphthyl)ethenyl>succinimide 
• 826-74-4 1-vinylnaphthalene 
• 141171-96-2 (Z)-1-(acetyloxy)-2-(1-naphthyl)ethylene 
• 141171-95-1 (E)-1-(acetyloxy)-2-(1-naphthyl)ethylene 
• 3506-84-1 4-(1-naphthyl)-2-butanone 
• 141171-89-3 3-(naphthalen-1-yl)but-3-en-2-ol 
• 941-98-0 1'-naphthacetophenone 
• 127087-65-4 (Z)-1-(2-butoxyethenyl)naphthalene 
• 127087-64-3 (E)-1-(2-butoxyethenyl)naphthalene 

Relevant academic research and scientific papers

Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

Nickel-Catalyzed Arylation/Alkenylation of tert-Cyclobutanols with Aryl/Alkenyl Triflates via a C - C Bond Cleavage

Herein, we first present a nickel-catalyzed arylation and alkenylation of tert-cyclobutanols with aryl/alkenyl triflates via a C-C bond cleavage. An array of γ-substituted ketones was obtained in moderate-to-good yields, thus featuring earth-abundant nick

Pd-Catalyzed Intermolecular Transthiolation of Ar-OTf Using Methyl 3-(Methylthio) Propanoate as a Thiol Surrogate

A method for the odorless synthesis of unsymmetrical sulfides via Csp2?O and Csp3?S bond activation is presented. Using methyl 3-(methylthio) propanoate as a MeSH surrogate, a series of substituted aryl methyl sulfides have been obtained in moderate to good yields. This catalytic protocol can also tolerate methyl 3-(methylthio)propionate derivatives to afford the corresponding aryl sulfides.

Palladium-Catalyzed Direct α-Arylation of Indane-1,3-dione to 2-Substituted Indene-1,3-diones

A straightforward and feasible palladium-catalyzed direct α-arylation of indane-1,3-dione to 2-substituted aryl/heteroaryl indene-1,3-diones has been disclosed for the first time. Optimization of reaction conditions identified tBu-XPhos as a preferred ligand for the bis(acetonitrile)dichloropalladium(II) catalyst. A broad spectrum of aryl iodides and aryl triflates containing electron-donating, electron-withdrawing, and sterically hindered substituents gave an excellent yield for the quick access α-arylated 1,3-diones library.

KRAS G12C INHIBITORS

The present invention relates to compounds that, inhibit KRas G12C, In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Palladium-Catalyzed Cyclobutanation of Aryl Sulfonates through both C-O and C-H Cleavage

A palladium-catalyzed cyclobutanation of aryl sulfonates with strained alkenes has been developed. The methodology is featured to achieve the cleavage of both C-O and C-H bonds of phenol derivatives in one pot. Under the reaction conditions, in addition t

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Practical Ni-Catalyzed Cross-Coupling of Unsaturated Zinc Pivalates with Unsaturated Nonaflates and Triflates

A practical nickel-catalyzed cross-coupling of (hetero)aryl or alkynylzinc pivalates with various unsaturated nonaflates or triflates is described. Organozinc pivalates allow these cross-couplings to take place with high yields and a low catalyst loading (0.5 mol %). Couplings with (E)- and (Z)-alkenyl triflates proceed with retention of configuration.

Nickel catalyzed decarboxylative alkylation of aryl triflates with anhydrides

Aliphatic acid anhydrides are the versatile building blocks and the new method for the conversion of anhydrides is thus of great significance. Herein, we report the decarboxylative alkylation of aryl triflates with aliphatic acid anhydrides via nickel catalysis. This novel method provides a facile access to construct Csp2-Csp3 bond. In addition, this method is compatible with a broad array of functional groups and exhibits good substrates scope.