32578-28-2Relevant academic research and scientific papers
Synthesis of Azidoanilines by the Buchwald-Hartwig Amination
Hosoya, Takamitsu,Sakata, Yuki,Yoshida, Suguru
, p. 15674 - 15688 (2021/11/16)
We report a Buchwald-Hartwig amination compatible with azido functionality. Treatment of azidoaryl iodides and amines with fourth-generation Buchwald precatalyst coordinated by CPhos and sodium tert-butoxide in 1,4-dioxane at 50 °C afforded the corresponding azidoanilines while leaving the azido groups intact. The method showed a broad substrate scope and was applicable to the synthesis of diazido compounds as photoaffinity probe candidates of pharmaceutical amines and multiazido platform molecules.
