325844-72-2Relevant academic research and scientific papers
Novel nucleoside analogues: First synthesis of pyridine-4-thioglycosides and their cytotoxic evaluation
Elgemeie, Galal,Abou-Zeid, Mamdouh,Alsaid, Shahinaz,Hebishy, Ali,Essa, Hanaa
, p. 659 - 673 (2015)
The reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with 2-cyano-N-arylacetamides afforded sodium pyridine-4-thiolates, coupling of the latters with 2,3,4,6-tetra-O-acetyl-D-gluco- and D-galactopyranosyl bromides, respectively, afforded new pyridine-4-thioglycosides. Ammonolysis of the latter compounds afforded the free thioglycosides. The antitumor activities of the synthesized compounds were tested against human tumor cell lines; lung (A549), colon (HCT116), liver (HEPG2), and prostate (PC3).
Novel 1,3-dithiolan-2-ones using sodium α-cyanoketene dithiolates
Elgemeie,Elghandour,Elzanaty,Ahmed
, p. 755 - 764 (2007/10/03)
A novel and efficient method for the synthesis of 1,3-dithiolan-2-ones using sodium α-cyanoketene dithiolates and monochloroacetic acid as starting components is described. Copyright Taylor & Francis Group, LLC.
Synthesis of novel derivatives of 4-methylthio-N-aryl-2-pyridone and deazapurine analogues: The reaction of ketene dithioacetals with substituted acetanilides
Elgemeie, Galal H.,Ali, Hosny A.,Elghandour, Ahmed H.,Abd Elaziz, Ghada W.
, p. 189 - 197 (2007/10/03)
A new one-pot synthesis of 4-methylthio-N-aryl-2-pyridones and their deazapurine analogues by the reaction of ketene dithioacetals with substituted acetanilides have been reported.
