Nucleosides, nucleotides and nucleic acids p. 659 - 673 (2015)
Update date:2022-08-05
Topics:
Elgemeie, Galal
Abou-Zeid, Mamdouh
Alsaid, Shahinaz
Hebishy, Ali
Essa, Hanaa
The reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with 2-cyano-N-arylacetamides afforded sodium pyridine-4-thiolates, coupling of the latters with 2,3,4,6-tetra-O-acetyl-D-gluco- and D-galactopyranosyl bromides, respectively, afforded new pyridine-4-thioglycosides. Ammonolysis of the latter compounds afforded the free thioglycosides. The antitumor activities of the synthesized compounds were tested against human tumor cell lines; lung (A549), colon (HCT116), liver (HEPG2), and prostate (PC3).
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