32585-06-1Relevant articles and documents
Synthesis of Isonitrile Derivatives of Diglycerides and Carbohydrates as Intermediates for Multicomponent Ugi Reaction
Cheshkov, D. A.,Khrulev, A. A.,Maslov, M. A.,Morozova, N. G.,Nichugovskiy, A. I.,Perevoshchikova, K. A.
, p. 929 - 938 (2021/08/25)
Abstract: Recently, there has been an increase in interest in multicomponent reactions, mainly due to the possibility of assembling of complex organic molecules in just several steps. Isocyanide is a key reagent for the Ugi multicomponent reaction. Isocyanide exhibits dual properties both electrophilic and nucleophilic. Several ways of formation of isonitrile derivatives are known, but the intramolecular dehydration of formamide is considered to be the main method. In this study, we synthesized isonitrile derivatives of dialkyl glycerol and D-glucose which can serve as new useful blocks for the creation of chemical libraries of lipophilic amines with the carbohydrate residue at their terminal nitrogen atom during the further interaction under the conditions of the multicomponent reactions. Structures of all the synthesized compounds were confirmed by physicochemical analytical methods, and these compounds can be used as blocks for the Ugi multicomponent reaction.
Synthesis ofN-alkylated lipopeptides and their application as organocatalysts in asymmetric Michael addition in aqueous environments
Corrêa, Arlene G.,Delgado, José A. C.,Fernandes, Vitor A.,Paix?o, Márcio W.,Vicente, Fidel E. M.,de la Torre, Alexander F.
supporting information, p. 14050 - 14057 (2021/08/16)
A library ofN-alkylated lipopeptide organocatalysts were synthesized through an isocyanide-based multicomponent reaction. Various structural motifs were tunably introduced on the catalyst backbone with the aim of incorporating amphiphilic features. Conseq
A double-carbamate aliphatic chain organic silane quaternary ammonium salt compound and its preparation and use
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Paragraph 0033-0036, (2017/03/18)
The invention relates to a propyl dimethicone formic ether aliphatic chain organosilane quaternary ammonium salt compound and preparation as well as application thereof. The structural formula of the compound is shown in the Specification, wherein X is Cl, Br and I; n ranges from 1 to 19, and m ranges from 1 to 9. The preparation method comprises the steps of mixing 3-dimethylamino-1,2-propylene glycol, triethylamine, methylbenzene and prepared aliphatic chain isocyanate, heating to 80 DEG C, and generating reation for 10 hours to obtain a carbamic acid ester midbody; mixing the carbamic acid ester midbody and haloalkylized trimethoxy silane, adding or not adding methylbenzene to heat the materials, cooling to a room temperature, and washing the product to obtain the propyl dimethicone formic ether aliphatic chain organosilane quaternary ammonium salt compound. The application of the propyl dimethicone formic ether aliphatic chain organosilane quaternary ammonium salt compound is that a propyl dimethicone formic ether aliphatic chain organosilane quaternary ammonium salt cation surfactant is added into mother liquor synthesized by a zeolite molecular sieve, then stirred and subjected to hydrothermal crystallization, suction filtration, washing, drying and roasting to obtain a multi-stage orifice zeolite molecular sieve. According to the propyl dimethicone formic ether aliphatic chain organosilane quaternary ammonium salt compound and the preparation as well as the application thereof, the pore volume and the specific surface area of the multi-stage orifice zeolite molecular sieve are obviously enlarged.
