3260-14-8Relevant academic research and scientific papers
New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C-N cross-coupling reaction of trans-4-hydroxy-l-proline with aryl halides
Reddy, V. Prakash,Kumar, A. Vijay,Rao, K. Rama
, p. 777 - 780 (2011)
trans-4-Hydroxy-l-proline is used for the first time as an effective nucleophilic coupling partner with aryl halides mediated by copper iodide with Cs2CO3 as the base and DMSO as the solvent. Utilizing this protocol cross-coupling of trans-4-hydroxy-l-proline with a wide variety of substituted aryl halides to produce N-aryl pyrroles in moderate to good yields.
An elegant protocol for the synthesis of N-substituted pyrroles through C-N cross coupling/aromatization process using CuFe2O4 nanoparticles as catalyst under ligand-free conditions
Satish,Reddy, K. Harsha Vardhan,Ramesh,Kumar, B.S.P. Anil,Nageswar
supporting information, p. 2596 - 2599 (2014/05/06)
A simple and efficient, ligand-free C-N cross-coupling of aryl halides/benzyl bromides with trans-4-hydroxy-l-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe2O4 nanoparticles, in the presence of Cs2CO3 in DMSO at 100 °C.
