32658-67-6

Basic information

• Product Name: 2-AMINO-5-IODOBENZAMIDE
• Synonyms: 2-AMINO-5-IODOBENZAMIDE
• CAS NO: 32658-67-6
• Molecular Formula: C₇H₇IN₂O
• Molecular Weight: 262.05
• Mol File: 32658-67-6.mol
• Article Data: 26

Chemical Properties

• Melting Point: 197-198 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 327.4°Cat760mmHg
• Flash Point: 151.8°C
• Appearance: /
• Density: 1.977g/cm³
• Vapor Pressure: 0.000203mmHg at 25°C
• Refractive Index: 1.719
• PKA: 15.21±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-5-IODOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-IODOBENZAMIDE(32658-67-6)
• EPA Substance Registry System: 2-AMINO-5-IODOBENZAMIDE(32658-67-6)

Safety Data

• Hazardous Substances Data: 32658-67-6(Hazardous Substances Data)

Usage

General Description

2-Amino-5-iodobenzamide is a chemical compound with the molecular formula C7H7IN2O. It is a derivative of the aromatic amide group and is used in the field of organic synthesis and pharmaceutical research. 2-AMINO-5-IODOBENZAMIDE has potential applications in the development of new drugs and has been studied for its interactions with biological systems. It may also have uses in the field of material science and as a building block in the synthesis of complex organic molecules. Its properties and reactivity make it a versatile and valuable compound for use in various scientific and industrial applications.

InChI:InChI=1/C7H7IN2O/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H2,10,11)

Upstream product

• 28144-70-9 anthranilic acid amide 
• 1397833-74-7 (2-amino-5-iodophenyl) (benzotriazole-1-yl)methanone 
• 116027-10-2 5-iodoisatoic anhydride 
• 20780-76-1 5-iodoisatin 
• 5326-47-6 2-amino-5-iodobenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 929695-95-4 2-(2,4-dihydroxy-phenyl)-6-iodo-3H-quinazolin-4-one 
• 928656-58-0 2-amino-5-(4-pyridinyl)benzamide 
• 16064-08-7 6-iodoquinazolin-4(3H)-one 
• 869299-00-3 ethyl ((2-(aminocarbonyl)-4-iodophenyl)amino)(oxo)acetate 
• 1158963-83-7 N-(2-carbamoyl-4-iodophenyl)furan-2-carboxamide 
• 1417283-64-7 2-benzoyl-6-iodoquinazolin-4(3H)-one 
• 13182-47-3 2-Benzoyl-4(3H)-quinazolinone 
• 257624-25-2 6-iodo-4-chloro-2-phenyl-quinazoline 
• 882523-91-3 4-chloro-2-(4-chlorophenyl)-6-iodoquinazoline 
• 82326-76-9 6-iodo-2-phenyl-3H,4H-quinazolin-4-one 
• 900468-68-0 2-(4-chlorophenyl)-6-iodo-3H-quinazolin-4-one 

Relevant articles and documents

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Visible-light induced copper(i)-catalyzed oxidative cyclization of: O -aminobenzamides with methanol and ethanol via HAT

The use of the in situ generated ligand-copper superoxo complex absorbing light energy to activate the alpha C(sp3)-H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.

Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates

An efficient and practical isatin-based oxidative domino protocol has been developed for the facile synthesis of 2-aminobenzamides and 2-aminobenzoates. The robust nature of this reaction system is reflected by accessible starting materials, room temperature and high-yield gram-scale synthesis.