32701-86-3

Upstream product

• 105-36-2 ethyl bromoacetate 
• 93-91-4 1-phenylbutan-1,3-dione 

Downstream Products

• 1412887-50-3 C₁₄H₁₄O₄ 
• 32701-88-5 [1-(4-chloro-phenyl)-3-methyl-5-phenyl-1H-pyrazol-4-yl]-acetic acid 
• 336185-50-3 3-(1-methylvinyl)-4-phenylpent-4-enal 
• 336185-49-0 ethyl 4-methyl-3-(1-phenylvinyl)pent-4-enoate 

Relevant academic research and scientific papers

Insight into the Rh-catalyzed cyclization of dissymmetrically racemic (±)-3,4-disubstituted 4-pentenal: Regio-, diastereo-, enantioselectivity, and kinetic resolution

Rh-Catalyzed cyclization was applied for the kinetic resolution of dissymmetrical (±)-3-(1-methylvinyl)-4-phenylpent-4-enal. The cyclization by a chiral neutral Rh[(S)-BINAP]Cl afforded a mixture of 3,4-cis-4-methylcyclopentanone (>95% ee, 19% yield), 3,4-trans-4-methylcyclopentanone, and 3,4-cis-4-phenylcyclopentanone (>95% ee, 21% yield). The cyclization by a cationic Rh[(R)-BINAP]ClO4 afforded a mixture of 3,4-trans-4-methylcyclopentanone (>95% ee, 36% yield), 3,4-cis-4-methyl-, and 3,4-trans-4-phenylcyclopentanone, accompanied with recovery of the starting material (-)-4-pentenal (54% ee, 34% yield), and by a cationic Rh[(S)-BINAP]ClO4 afforded the corresponding enantiomers. The course of the cyclization and the stereochemistry of products are discussed based on the plausible acyl-hydride rhodium intermediates.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.