844856-98-0

Upstream product

• 100-39-0 benzyl bromide 
• 844856-96-8 [2-hydroxy-2-(8-hydroxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 844856-94-6 [2-hydroxy-1-(4-methoxybenzyl)-2-(8-oxo-1,4-dioxaspiro[4.5]dec-7-yl)ethyl]carbamic acid tert-butyl ester 
• 139183-60-1 N-t-butoxylcarbonyl-O-methyl-L-tyrosinal 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 844857-25-6 N-[7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]-N-methylcarbamic acid tert-butyl ester 
• 844857-09-6 (1S,3S,6S,7S,8S,9S)-7,9-Bis-benzyloxy-6-(4-methoxy-benzyl)-5-aza-tricyclo[6.3.1.0^1,5]dodecane-3-carbonyl azide 
• 844857-12-1 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]carbamic acid methyl ester 
• 844857-02-9 1-[(1S,2S)-2-Benzyloxy-2-((7S,8S)-8-benzyloxy-1,4-dioxa-spiro[4.5]dec-7-yl)-1-(4-methoxy-benzyl)-ethylamino]-but-3-en-2-ol 
• 844857-11-0 7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodecane-3-carboxylic acid 
• 844857-08-5 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]methanol 
• 844857-14-3 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl]methanol 
• 844857-10-9 [7,9-bisbenzyloxy-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1.5]dodec-3-yl](methyl)amine 

Relevant academic research and scientific papers

Total synthesis of (-)-FR901483

A total synthesis of the immunosuppressive alkaloid (-)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone deriv

A formal total synthesis of (-)-FR901483, using a tandem cationic aza-Cope rearrangement/Mannich cyclization approach

(Chemical Equation Presented) A formal total synthesis of the immunosuppressant FR901483 has been accomplished. The key step in the synthesis utilizes a tandem cationic aza-Cope rearrangement/Mannich cyclization reaction for accessing the unprecedented br