3273-44-7

Usage

Uses

Used in Pharmaceutical Industry:
5-methyl-1H-pyrazole-3-carbaldehyde is used as a building block for the synthesis of various pharmaceuticals, leveraging its chemical properties to contribute to the development of new medications.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 5-methyl-1H-pyrazole-3-carbaldehyde serves as a key component in the creation of different agrochemicals, potentially enhancing crop protection and yield.
Used in Medicinal Chemistry:
5-methyl-1H-pyrazole-3-carbaldehyde is utilized as an intermediate in medicinal chemistry, playing a crucial role in the advancement of drug discovery and the design of novel therapeutic agents.
Used in Chemical Research:
In the field of chemical research, 5-methyl-1H-pyrazole-3-carbaldehyde is employed as a subject of study, facilitating investigations into the properties and reactions of pyrazole derivatives, which can lead to the uncovering of new chemical insights and applications.
Used in Drug Development:
As a component in drug development, 5-methyl-1H-pyrazole-3-carbaldehyde is instrumental in the formulation and optimization of new drugs, contributing to the improvement of existing medications or the invention of new treatment options.

InChI:InChI=1/C5H6N2O/c1-4-2-5(3-8)7-6-4/h2-3H,1H3,(H,6,7)

Upstream product

• 1117-96-0 Diazoethan 
• 624-67-9 Propargylic aldehyde 
• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 
• 124237-06-5 1,1-diethoxy-2,4-pentandione 
• 3256-01-7 5-diethoxymethylen-3-methylpyrazole 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 3256-01-7 3-diethoxymethylen-5-methylpyrazole 

Downstream Products

• 926893-81-4 5-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole 
• 196865-65-3 1,2-di(3'-formyl-5'-methyl-1'-pyrazolyl)ethane 

Relevant academic research and scientific papers

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies

Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb suggested a novel mechanism of action. The compounds were bactericidal against replicating Mtb and retained potency against clinical isolates of Mtb. Although selected MmpL3 mutant strains of Mtb showed resistance to these compounds, there was no shift in the minimum inhibitory concentration (MIC) against a mmpL3 hypomorph, suggesting mutations in MmpL3 as a possible resistance mechanism for the compounds but not necessarily as the target. RNA transcriptional profiling and the checkerboard board 2D-MIC assay in the presence of varying concentrations of ferrous salt indicated perturbation of the Fe-homeostasis by the compounds. Structure-activity relationship studies identified potent compounds with good physicochemical properties and in vitro microsomal metabolic stability with moderate selectivity over cytotoxicity against mammalian cell lines.

Compounds Based on a Triethyl- or Trimethoxybenzene Scaffold Bearing Pyrazole, Pyridine, and Pyrimidine Groups: Syntheses and Representative Binding Studies towards Carbohydrates

Pyrazole-based artificial receptors have often been used in the recognition of ions, but in the area of sugar recognition the potential of pyrazole-based recognition groups has only been rarely examined. In this paper we describe the syntheses of twelve n

LRRK2 INHIBITORS

Provided herein are compounds that inhibit or partially inhibit the activity of leucine rich repeat kinases. Also provided herein are methods of treatment of CNS disorders comprising administration of inhibitors of leucine rich repeat kinases.

Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof

The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represente

Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof

The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represente

TRICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS

Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Benzimidazole derivatives and their use as KDR kinase protein inhibitors

The invention discloses and claims benzimidazole compounds of formula (I): wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl or a saturated 5- or 6-membered monocyclic heterocyclic radical or a b

Porphyrins with four azole substituents in meso positions: X-ray crystal structure of meso-tetrakis-(1-benzylpyrazol-4-yl)-porphyrin at 200 K

Several new porphyrins have been prepared in improved yields using an established method which was adapted to formylpyrazoles bearing on the pyrazole N1-nitrogen protective groups. The deprotection of N-para-methoxybenzyl and SEM protected meso