32749-55-6

Usage

Uses

Used in Pharmaceutical Industry:
1-benzyl-6-oxopiperidine-3-carboxylic acid is used as a building block for the synthesis of pharmaceutical drugs due to its potential biological activity and versatile chemical structure. Its presence in the development of new drugs can contribute to the discovery of novel therapeutic agents.
Used in Organic Synthesis:
1-benzyl-6-oxopiperidine-3-carboxylic acid is used as an intermediate in organic synthesis for the production of various organic molecules. Its functional groups allow for further chemical reactions, making it a useful component in creating complex organic compounds.
Used in Research and Development:
1-benzyl-6-oxopiperidine-3-carboxylic acid is used as a research tool in the study of piperidine derivatives. Its unique structure and potential biological activity make it valuable for understanding the properties and applications of related compounds in scientific research.
Used in Fine Chemicals Production:
1-benzyl-6-oxopiperidine-3-carboxylic acid is used as an intermediate in the production of fine chemicals. Its role in creating specialty chemicals highlights its importance in various industrial applications, including the development of high-quality materials and products.

Upstream product

• 100-46-9 benzylamine 
• 5621-43-2 diethyl 2-methyleneglutarate 
• 4332-79-0 1-benzyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 100-39-0 benzyl bromide 
• 156779-10-1 1,4,5,6-tetrahydro-6-oxo-1-(phenylmethyl)-3-pyridinecarboxylic acid methyl ester 
• 14376-92-2 (E/Z)-methyl 3-(benzylamino)acrylate 
• 156779-11-2 1-benzyl-6-oxopiperidine-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines

The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.

CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

A compound of the formula: wherein R1 is a hydrocarbon group, R2 is a hydrocarbon group having 2 or more carbon atoms, where R1 and R2 may in combination form, together with an adjacent nitrogen atom, a ring optionally having a substituent or substituents, R3 is a hydrocarbon group optionally having a substituent or substituents or a heterocyclic group optionally having a substituent or substituents, R4 is a hydrogen atom, a hydrocarbon group, a heterocyclic group and the like, E is a divalent chain hydrocarbon group and the like, G is CO or SO2, J is a nitrogen atom, a methine group and the like, and Q and R are each a divalent chain C1-3 hydrocarbon group and the like, and a salt thereof show a superior CCR5 antagonistic activity and are useful as agents for the prophylaxis or treatment of HIV infection of human peripheral blood mononuclear cells, particularly AIDS.

Construction of Hydroxylated Alkaloids (+/-)-Mannonolactam, (+/-)-Deoxymannojirimycin, and (+/-)-Prosopinine through Aza-Annulation

The aza-annulation of β-enamino carbonyl substrates with acrylate derivatives provides an efficient and convenient route for the regioselective construction of δ-lactams.This two-step ring-forming sequence involved initial generation of the benzyl enamine through either a condensation or conjugate addition reaction with BnNH2, followed by aza-annulation with acryloyl chloride or acrylic anhydride.Controlled by the rigid framework of the intermediate lactam, introduction of ring substituents was accomplished with high relative stereoselectivity.The carbonyl functionality, which was necessary to direct the regioselectivity of the aza-annulation reaction, was then transformed into a protected hydroxyl substituent through Baeyer-Villiger oxidation.The resultant δ-lactam product was used as a valuable intermediate in the synthesis of three natural products.Subsequent modification of this δ-lactam gave the naturally occurring α-mannosidase inhibitors (+/-)-mannonolactam and (+/-)-deoxymannojirimycin, while synthesis of the alkaloid (+/-)-prosopinine was accomplished through homologation of the lactam carbonyl.