4332-79-0

Basic information

• Product Name: 1-BENZYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLIC ACID
• Synonyms: IFLAB-BB F2143-0001;1-BENZYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylicacid, 1,6-dihydro-6-oxo-1-(phenylmethyl)-
• CAS NO: 4332-79-0
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23
• Mol File: 4332-79-0.mol

Chemical Properties

• Melting Point: 205-207°C
• Boiling Point: 443.3 °C at 760 mmHg
• Flash Point: 221.9 °C
• Appearance: /
• Density: 1.355 g/cm³
• Vapor Pressure: 1.22E-08mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.83±0.50(Predicted)
• CAS DataBase Reference: 1-BENZYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLIC ACID(4332-79-0)
• EPA Substance Registry System: 1-BENZYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLIC ACID(4332-79-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 4332-79-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid is utilized as an intermediate in the synthesis of a variety of drugs and pharmaceutical products. Its structural attributes make it a key component in the creation of molecules with potential biological activities, which can be harnessed for the treatment of different medical conditions. 1-BENZYL-6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLIC ACID's versatility in chemical reactions allows for the exploration of its use in developing innovative therapeutic agents.

InChI:InChI=1/C13H11NO3/c15-12-7-6-11(13(16)17)9-14(12)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,16,17)

Upstream product

• 59-67-6 nicotinic acid 
• 100-44-7 benzyl chloride 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 6018-41-3 methyl coumalate 
• 100-46-9 benzylamine 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 100-39-0 benzyl bromide 
• 857202-29-0 1-benzyl-5-(2-methyl-[1,3]dioxolan-2-yl)-1H-pyridin-2-one 
• 5096-13-9 1-benzylnicotinamide chloride 
• 107971-00-6 1-benzyl-1,6-dihydro-6-imino-3-pyridiniumcarboxamide 
• 32684-80-3 5-acetyl-1-benzylpyridin-2(1H)-one 

Downstream Products

• 24903-84-2 Ethyl-1-benzyl-1,6-dihydro-6-oxopyridin-3-carboxylat 
• 201294-64-6 1-Benzyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl chloride 
• 906069-99-6 2-{1-[(1-benzyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl)-amino]-cyclopentylmethyl}-pentanoic acid tert-butyl ester 
• 201294-66-8 1-benzyl-6-oxo-1,6-dihydropyridine-3-carbaldehyde 
• 201294-65-7 1-benzyl-5-(hydroxymethyl)pyridin-2(1H)-one 
• 242472-07-7 1-benzyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid hydrazide 
• 1037087-50-5 tert-butyl (2S)-2-{[(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)carbonyl]amino}-5-{[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]carbamimidamido}pentanoate 
• 32749-55-6 1-benzyl-6-oxopiperidine-3-carboxylic acid 

Relevant articles and documents

Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines

The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.

MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF

Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.