32750-26-8

Usage

Nitrophenol derivative

A class of organic compounds 2-(tert-butyl)-6-iodo-4-nitrophenol belongs to the nitrophenol class, which contains both a nitro group (-NO2) and a phenolic hydroxyl group.

Tert-butyl group

A type of alkyl group The compound features a tert-butyl group (a specific type of alkyl group) attached to the benzene ring.

Iodine atom

A halogen element The presence of an iodine atom in the compound provides unique properties and reactivity.

Nitro group

A functional group with -NO2 The compound contains a nitro group, which may contribute to its potential toxicity.

Hydroxyl group

A functional group with -OH The presence of a hydroxyl group on the benzene ring influences the compound's reactivity and properties.

Benzene ring

Aromatic structure The compound's core structure is a benzene ring, which is an aromatic and stable arrangement of carbon and hydrogen atoms.

Potential applications

Organic chemistry, pharmaceuticals, and chemical products 2-(tert-butyl)-6-iodo-4-nitrophenol has possible uses in various fields, including the synthesis of pharmaceuticals and other chemical products.

Toxicity

Caution required in handling and usage Due to the presence of a nitro group, 2-(tert-butyl)-6-iodo-4-nitrophenol may have some toxicity, and it should be handled with care in laboratory or industrial settings.

Upstream product

• 88-18-6 2-tert-Butylphenol 
• 6683-81-4 2-tert-butyl-4-nitrophenol 

Downstream Products

• 1132940-43-2 1-tert-butyl-3-iodo-2-methoxy-5-nitrobenzene 
• 1132937-45-1 N-(4-((3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethynyl)phenyl)methanesulfonamide 
• 1132940-49-8 1-(3-tert-butyl-5-iodo-4-methoxyphenyl )dihydropyrimidine-2,4(1H,3H)-dione 
• 1132940-45-4 3-tert-butyl-5-iodo-4-methoxyaniline 
• 1132940-55-6 1-bromo-3-tert-butyl-2-methoxy-5-nitrobenzene 

Relevant academic research and scientific papers

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to impr

URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C

Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such interm