32767-68-3

Basic information

• Product Name: 2-Isobutoxytetrahydro-2H-pyran
• Synonyms: 2-(2-Methylpropoxy)tetrahydro-2H-pyran;2-Isobutoxytetrahydro-2H-pyran;Tetrahydro-2-(isobutyloxy)-2H-pyran
• CAS NO: 32767-68-3
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.27
• Mol File: 32767-68-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 223.34°C (rough estimate)
• Flash Point: 51.6°C
• Appearance: /
• Density: 0.9003 (rough estimate)
• Vapor Pressure: 0.938mmHg at 25°C
• Refractive Index: 1.4350 (estimate)
• CAS DataBase Reference: 2-Isobutoxytetrahydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isobutoxytetrahydro-2H-pyran(32767-68-3)
• EPA Substance Registry System: 2-Isobutoxytetrahydro-2H-pyran(32767-68-3)

Safety Data

• Hazardous Substances Data: 32767-68-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H18O2/c1-8(2)7-11-9-5-3-4-6-10-9/h8-9H,3-7H2,1-2H3

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 78-83-1 2-methyl-propan-1-ol 
• 78-94-4 methyl vinyl ketone 
• 6581-67-5 2-Isobutoxy-3,4-dihydro-2H-pyran 

Downstream Products

• 78-83-1 2-methyl-propan-1-ol 
• 142-68-7 TETRAHYDROPYRANE 

Relevant articles and documents

Anhydrous FePO4 as a cost-effective and recyclable catalyst for tetrahydropyranylation and tetrahydrofuranylation of alcohols and phenols

In this article, a mild and efficient protocol for the tetrahydropyranylation and tetrahydrofuranylation of various aliphatic and benzylic alcohols and phenols into their corresponding THP and THF ethers (with 3,4-dihydro- 2H-pyran, DHP and 2,3-dihydrofuran, DHF) has been developed using a catalytic amount of anhydrous FePO4 at room temperature and relatively short reaction times in good to excellent yields.

Metal benzenesulfonates/acetic acid mixtures as novel catalytic systems: Application to the protection of a hydroxyl group

A surprising synergistic effect has been discovered in mixtures of metal benzenesulfonates (Co, Al, Ni, Zn, Cd, Pr, La, Cu, Mn) and acetic acid, leading to active catalytic systems for the tetrahydropyranylation of alcohols and phenols to produce tetrahydropyranyl ethers. All reactions proceed mildly and efficiently with moderate to high yields at room temperature without solvent. After the reaction, the metal benzenesulfonate can be easily recovered and reused many times. The efficiency of these systems might result from the "double activation" by Bronsted and Lewis acid catalysis.

Copper nitrate/acetic acid as an efficient synergistic catalytic system for the chemoselective tetrahydropyranylation of alcohols and phenols

Tetrahydropyranylation of alcohols and phenols was accomplished successfully using copper nitrate and acetic acid as a synergistic catalyst at room temperature under solvent-free condition. Compared with other synergistic catalytic systems, copper nitrate/acetic acid proved to be the most efficient. Both alcohols (primary, secondary, tertiary, benzylic, cyclic, allyl, cinnamyl, and furyl) and phenols reacted smoothly in high yields. Graphical abstract: [Figure not available: see fulltext.]