32783-79-2

Upstream product

• 90839-63-7 (2R)-1,1,3,3-tetramethyl-1,2,4-butanetriol 1-benzoate 
• 98-88-4 benzoyl chloride 
• 5522-92-9 2,2-dimethyl-1,3-propanediol 1-benzoate 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 

Downstream Products

• 5522-92-9 2,2-dimethyl-1,3-propanediol 1-benzoate 
• 75-84-3 2,2-dimethyl-propanol-1 
• 90839-64-8 Benzoic acid 3-methanesulfonyloxy-2,2-dimethyl-propyl ester 
• 100-51-6 benzyl alcohol 
• 1416254-77-7 2,2-dimethylbut-3-en-1-yl benzoate 
• 1416254-81-3 2,2-dimethyloctyl benzoate 

Relevant academic research and scientific papers

Dithiocarbamate-substituted gem-difluorinated silicon reagent: generation and addition to aldehydes

Abstract A new gem-difluorinated silicon reagent bearing a pyrrolidine dithiocarbamate substituent was prepared by the reaction of (bromodifluoromethyl)trimethylsilane with the corresponding potassium dithiocarbamate. The obtained reagent was employed in

MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS

Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents the treatment of inflammatory diseases and conditions.

SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.

Steric Course of N5,N10-Methylenetetrahydrofolate Formation from Glycine by the Glycine Cleavage System in E. coli

The steric course of the conversion of glycine to 5,10-methylenetetrahydrofolate (5,10-CH2-H4folate) by the glycine cleavage system in E. coli has been elucidated. 2-Hre of glycine is the precursor of 11-Hre of 5,10-CH2-H4folate, and 2-Hsi of glycine is the precursor of 11-Hsi of 5,10-CH2-H4folate.The overall transformation is at least 78percent stereospecific (possibly higher).