328552-93-8Relevant academic research and scientific papers
CARDIAC SARCOMERE INHIBITORS
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Paragraph 0250, (2020/01/24)
Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, Y1, Y2, L1, and G1 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Novel, potent non-covalent thrombin inhibitors incorporating P3-lactam scaffolds
Ho, Jonathan Z.,Gibson, Tony S.,Semple
, p. 743 - 748 (2007/10/03)
Evolution of P1-argininal inhibitor prototypes led to a series of non-covalent P3-7-membered lactam inhibitors 1a-w, featuring novel peptidomimetic units that probe each of the S1, S2, and S3 specificity pockets of thrombin. Rigid P1-arginine surrogates possessing a wide range of basicity (calcd pKa's～neutral-14) were surveyed. The design, synthesis, and biological activity of these targets are presented.
