328-68-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-5-(trifluoromethyl)benzoic acid is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be incorporated into complex molecular structures. Its presence in drug molecules can influence properties such as solubility, stability, and bioavailability, which are crucial for drug efficacy and safety.
Used in Chemical Research:
3-Amino-5-(trifluoromethyl)benzoic acid is used as a research compound in the field of synthetic organic chemistry. It serves as a model for studying the effects of trifluoromethyl and amino substitutions on the reactivity and properties of benzene derivatives, contributing to the development of new synthetic methods and understanding of chemical reactions.
Used in Material Science:
3-Amino-5-(trifluoromethyl)benzoic acid is used as a building block in the development of new materials with specific properties. Its incorporation into polymers or other materials can impart unique characteristics, such as increased thermal stability or altered electronic properties, which can be exploited in various applications, including electronics and coatings.

Upstream product

• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 

Downstream Products

• 955947-15-6 3-isothiocyanato-5-trifluoromethyl-benzoic acid 
• 328-69-8 3-hydroxy-5-(trifluoromethyl)benzoic acid 
• 328-67-6 3-bromo-5-(trifluoromethyl)benzoic acid 
• 1357582-09-2 3-amino-N-[3-(1H-tetrazol-5-yl)-phenyl]-5-trifluoromethyl-benzamide 
• 1247019-14-2 (R)-3-(amino)-N-(1-phenylethyl)-5-(trifluoromethyl)benzamide 
• 1229454-66-3 3-amino-N-isopropyl-5-(trifluoromethyl)benzamide 
• 942077-27-2 3-(tert-butyl-dimethyl-silanyloxymethyl)-5-trifluoromethyl-phenylamine 
• 53985-49-2 3-chloro-5-(trifluoromethyl)benzoic acid 
• 1044272-24-3 3-(8-isopropyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-5-trifluoromethyl-benzoic acid 
• 900799-10-2 3-benzyloxycarbonylamino-5-trifluoromethyl-benzoic acid 
• 157383-40-9 5-trifluoromethyl-3-N, N-dimethylaminobenzoylguanidine hydrochloride 
• 53604-84-5 3-chlorosulfonyl-5-(trifluoromethyl)benzoic acid 
• 955953-25-0 3-(2-carbamoyl-2-cyano-thioacetylamino)-5-trifluoromethyl-benzoic acid 
• 630125-98-3 3-amino-N,N-dimethyl-5-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Enantioselective Synthesis of Quaternary Δ4- and Δ5-Dehydroprolines Based on a Two-Step Formal [3+2] Cycloaddition of α-Aryl and α-Alkyl Isocyano(thio)acetates with Vinyl Ketones

A divergent synthesis of optically active quaternary Δ4- and Δ5-dehydro prolines is developed based on the first catalytic enantioselective conjugate addition of α-substituted isocyano(thio)acetates to vinyl ketones that is general for both α-aryl and α-alkyl isocyano(thio)acetates. The new tetrasubstituted C?N stereocenter is formed without the need of any metal salt due to a bifunctional tertiary amine/squaramide catalyst, featuring a bulky polyaryl sidearm and an unusually short squaramide diamide H???H interatomic distance in the solid state.

Catalytic Asymmetric Synthesis of Quaternary Barbituric Acids

The catalytic asymmetric α-functionalization of prochiral barbituric acids, a subtype of pseudosymmetric 1,3-diamides, to yield the corresponding 5,5-disubstituted (quaternary) derivatives remains essentially unsolved. In this study 2-alkylthio-4,6-dioxopirimidines are designed as key 1,3-diamide surrogates that perform exceedingly in amine-squaramide catalyzed C-C bond forming reactions with vinyl ketones or Morita-Baylis-Hillmann-type allyl bromides as electrophiles. Mild acid hydrolysis of adducts affords barbituric acid derivatives with an in-ring quaternary carbon in unprecedented enantioselectivity, offering valuable materials for biological evaluations.

NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

PIPERIDINE DERIVATIVE AND USE THEREOF

The present invention provides a novel piperidine derivative and a tachykinin receptor antagonist containing same, as well as a compound represented by the formula:wherein R1 is carbamoylmethyl, methylsulfonylethylcarbonyl and the like; R2 is methyl or cyclopropyl; R3 is a hydrogen atom or methyl; R4 is a chlorine atom or trifluoromethyl; R5 is a chlorine atom or trifluoromethyl; and a group represented by the formula:is a group represented by the formula:wherein R6 is a hydrogen atom, methyl, ethyl or isopropyl; R7 is a hydrogen atom, methyl or a chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine atom or methyl; or 3-methylthiophen-2-yl, and a salt thereof.

Dibenzyl Amine Compounds and Derivatives

Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

NOVEL PYRIMIDINEAMIDE DERIVATIVES AND THE USE THEREOF

The invention relates to novel substituted N-(3-benzoylaminophenyl)-4-pyridyl-2-pyrimidinarnine derivatives, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more oth

META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagoniz

META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES

The present invention relates to a class of compounds represented by the Formula Ior a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphavbeta3 integrin.