32806-04-5

Basic information

• Product Name: Diethyl (Methoxymethyl)phosphonate
• Synonyms: Diethyl (Methoxymethyl)phosphonate;(Methoxymethyl)phosphonic Acid Diethyl Ester;15895-A1;1-[ethoxy(methoxymethyl)phosphoryl]oxyethane
• CAS NO: 32806-04-5
• Molecular Formula: C₆H₁₅O₄P
• Molecular Weight: 182.154661
• Mol File: 32806-04-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 88°C/6mmHg(lit.)
• Flash Point: 100.779°C
• Appearance: /
• Density: 1.066g/cm³
• Vapor Pressure: 0.175mmHg at 25°C
• Refractive Index: 1.4220-1.4260
• CAS DataBase Reference: Diethyl (Methoxymethyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl (Methoxymethyl)phosphonate(32806-04-5)
• EPA Substance Registry System: Diethyl (Methoxymethyl)phosphonate(32806-04-5)

Safety Data

• Hazardous Substances Data: 32806-04-5(Hazardous Substances Data)

Usage

General Description

Diethyl (methoxymethyl)phosphonate is a chemical compound with the formula C7H17O4P. It is a phosphonate ester and is commonly used as an intermediate in the synthesis of organic compounds. Diethyl (methoxymethyl)phosphonate can also act as a potential starting material for the preparation of biological active organophosphorus compounds. It is a colorless liquid with a pungent odor and is soluble in water and most organic solvents. The compound has been studied for its potential use in pharmaceuticals, agrochemicals, and as a flame retardant. It is important to handle this chemical with care as it is potentially harmful if ingested, inhaled, or in contact with the skin.

InChI:InChI=1/C6H15O4P/c1-4-9-11(7,6-8-3)10-5-2/h4-6H2,1-3H3

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 762-04-9 phosphonic acid diethyl ester 
• 122-52-1 triethyl phosphite 
• 3084-40-0 diethyl (1-hydroxymethyl)phosphonate 
• 74-88-4 methyl iodide 
• 589-57-1 diethyl phosphorylchloridite 
• 625-45-6 2-methoxyacetic acid 
• 21646-99-1 diphosphorous acid tetraethyl ester 
• 64-17-5 ethanol 
• 13057-19-7 Iodomethyl methyl ether 
• 2303-76-6 sodium diethyl phosphite 
• 13057-17-5 bromethyl methyl ether 

Downstream Products

• 1574232-45-3 diethyl (1-methoxy-2-oxo-2-phenylethyl)phosphonate 
• 1574233-03-6 diethyl (1S,2S)-(1-methoxy-2-hydroxy-2-phenylethyl)phosphonate 

Relevant articles and documents

Oral Delivery of Propofol with Methoxymethylphosphonic Acid as the Delivery Vehicle

Phosphonamidate 3a of methoxymethylphosphonic acid (MMPA) with propofol (1) and l-alanine ethyl ester was found to be an efficient scaffold for the oral delivery of compound 1. The synthesis and evaluation of MMPA based phosphonamidates of compound 1, HSK3486 (2), and other phenolic drugs revealed the general application of MMPA as the effective delivery vehicle for phenolic drugs. On the basis of plasma concentrations of compound 1 and SN38 (14), the oral bioavailability of compound 3a and 15 in beagle dogs was found to be 97.6% and 34.1%, respectively.

METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN ALPHA-OXY PHOSPHORUS GROUP BY USING P-X COMPONENTS

A method for the manufacture of compounds containing an α- oxy phosphorus group is disclosed. A P-X component having at least one P-X bond, whereby the phosphorus of the P-X bond has the +3 oxidation state with X being C1 or Br, is reacted in a specific equivalent ratio with a compound containing an α-oxy carboxylic acid group, followed by conducting the reaction and optionally adding a quenching agent at the end of the reaction. The compounds containing an α-oxy phosphorus group formed are then recovered.

A Convenient One-pot Synthesis of Polyenic Enol Ethers

Diethyl alkoxymethylphosphonates react with unsaturated aldehydes to give polyenic enol ethers with a good stereoselectivity.