328062-37-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinamine, 4-imidazo[1,2-a]pyridin-3-ylis used as an intermediate in the synthesis of various pharmaceuticals for its potential therapeutic applications in the treatment of diseases such as cancer and diabetes.
Used in Agrochemical Industry:
2-Pyrimidinamine, 4-imidazo[1,2-a]pyridin-3-ylis used as an intermediate in the synthesis of various agrochemicals for its potential applications in agriculture.
Used in Antimicrobial Applications:
2-Pyrimidinamine, 4-imidazo[1,2-a]pyridin-3-ylhas been studied for its antimicrobial properties, making it a potential candidate for use in the development of new antimicrobial agents.
Used in Antiviral Applications:
2-Pyrimidinamine, 4-imidazo[1,2-a]pyridin-3-ylhas been studied for its antiviral properties, making it a potential candidate for use in the development of new antiviral agents.

Upstream product

• 504-29-0 2-aminopyridine 
• 29096-60-4 1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone 
• 328062-30-2 3-(3-dimethylaminoprop-2-en-1-oyl)imidazo[1,2-a]pyridine 
• 50-01-1 guanidine hydrochloride 
• 113-00-8 guanidine nitrate 
• 264606-78-2 4-(2-methyl-imidazo[1,2-a]pyridin-3-yl)-pyrimidine-2-thiol 

Downstream Products

• 328061-46-7 2-anilino-4-(imidazo[1,2-a]pyrid-3-yl)pyrimidine 
• 328062-09-5 5-bromo-2-{4-[N-(2-methoxy-ethyl)sulphamoyl]anilino}-4-(imidazo[1,2-a]pyrid-3-yl)pyrimidine 

Relevant academic research and scientific papers

Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors

Exploration of SAR and optimisation of the imidazo[1,2-a]pyridine CDK inhibitors has lead to the discovery of novel, potent and selective inhibitors of the cyclin-dependent kinase CDK2. Understanding of SAR has identified positions of substitution, which allow modification of physical properties and offer the potential for in vivo optimisation.

IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES

A compound of formula (I) wherein Ring A is imidazol[1,2a]pyrid-3-yl or pyrazolo[2,3a]pyrid-3-yl; Ris as defined within; m is 0-5; wherein the values of Rmay be the same or different; Ris as defined within; n is 0 to 2, wherein the values of Rmay be the same or different; Ring B is phenyl or phenyl fused to a C5-7cycloalkyl ring; Ris as defined within; p is 0-4; wherein the values of Rmay be the same or different; Ris as defined within; q is 0-2; wherein the values of Rmay be the same or different; and wherein p+q=5; or a pharmaceutically acceptable salt or an in vivo hydrolyzable ester thereof is described. The use of compounds of formula (I) in the inhibition of cell cycle kinases CDK2, CDK4, and CDK6 are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.