328084-04-4

Basic information

• Product Name: 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine
• Synonyms: 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine
• CAS NO: 328084-04-4
• Molecular Weight: 273.205
• Mol File: 328084-04-4.mol

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine(328084-04-4)
• EPA Substance Registry System: 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine(328084-04-4)

Safety Data

• Hazardous Substances Data: 328084-04-4(Hazardous Substances Data)

Upstream product

• 701237-08-3 4-(tert-butoxycarbonyl)(methyl)amino-1-(3,4-dichlorobenzyl)piperidine 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 328083-79-0 4-tert-butoxycarbonylamino-1-(3,4-dichlorobenzyl)piperidine 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 
• 7144-05-0 4-Aminomethylpiperidine 
• 74-89-5 methylamine 
• 220772-52-1 1-(3,4-dichlorobenzyl)-4-piperidone 

Relevant articles and documents

Substituted piperidine compounds useful as modulators of chemokine receptor activity

The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions

PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM

The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts thereof, or pharmaceutically acceptable C1-C6 alkyl adducts thereof, as well as pharmaceutical compositions comprising them as effective ingredients, which are useful for treatment or prevention of diseases associated with CCR3, such as asthma and allergic rhinitis.

Structure-activity relationships of 2-(benzothiazolylthio)acetamide class of CCR3 selective antagonist

The structure activity relationships of novel selective CCR3 receptor antagonists, 2-(benzothiazolylthio)acetamimde derivatives were described. A lead structure (1a) was discovered from the screening of the focused library that was based on the structure