328088-13-7

Upstream product

• 3959-05-5 2-bromobenzylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 18982-54-2 o-bromobenzyl alcohol 
• 70-55-3 toluene-4-sulfonamide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 106-45-6 para-thiocresol 
• 254428-46-1 (E)-N-(2-bromobenzylidene)-4-methylbenzenesulfonamide 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 5465-63-4 2-bromobenzylamine hydrochloride 

Downstream Products

• 127459-01-2 2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-1H-isoindol-1-one 
• 936546-05-3 4-methyl-N-(2-vinylbenzyl)benzenesulfonamide 
• 81097-20-3 N-(2-allyl-benzyl)-4-methyl-benzenesulfonamide 
• 1231753-23-3 dimethyl 2-(but-2-ynyl)-2-(3-(2-((4-methylphenylsulfonamido)-methyl)phenyl)prop-2-ynyl)malonate 
• 1527501-92-3 6-tosyl-5,6-dihydroindolo[1,2-a]quinazoline 
• 1280639-58-8 (R,S)-2-hydroxyethyl 2-(2-tosylisoindolin-1-yl)acetate 
• 1280639-64-6 (R,S)-2-(2-tosylisoindolin-1-yl)acetic acid 
• 1280639-60-2 (R,S)-2-(2-tosylisoindolin-1-yl)acetamide 
• 1280639-62-4 (R,S)-2-(2-tosylisoindolin-1-yl)acetonitrile 
• 1280639-65-7 (R,S)-1-(2-tosylisoindolin-1-yl)propan-2-one 
• 1280639-55-5 (R,S)-butyl 2-(2-tosylisoindolin-1-yl)acetate 
• 875313-00-1 3-benzyloxy-4-methylene-2-(4-methylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 328088-06-8 p-tert-butylphenyl 4-[N-(2-bromobenzyl)-N-tosylamino]-6-O-(tert-butyldimethylsilyl)-2,3,4-trideoxy-α-D-erythro-hex-2-enopyranoside 
• 405198-84-7 N-[2-[2-(trimethysilyl)ethynyl]benzyl]-(4-methylphenyl)sulfonamide 

Relevant academic research and scientific papers

Amide Iridium Complexes As Catalysts for Transfer Hydrogenation Reduction of N-sulfonylimine

Sulfonamide moieties widely exist in natural products, biologically active substance, and pharmaceuticals. Here, an efficient water-soluble amide iridium complexes-catalyzed transfer hydrogenation reduction of N-sulfonylimine is developed, which can be carried out under environmentally friendly conditions, affording a series of sulfonamide compounds in excellent yields (96-98%). In comparison with organic solvents, water is shown to be critical for a high catalytic transfer hydrogenation reduction in which the catalyst loading can be as low as 0.001 mol %. These amide iridium complexes are easy to synthesize, one structure of which was determined by single-crystal X-ray diffraction. This protocol gives an operationally simple, practical, and environmentally friendly strategy for synthesis of sulfonamide compounds.

Metal-Free Aminoiodination of Alkynes Under Visible Light Irradiation for the Construction of a Nitrogen-Containing Eight-Membered Ring System

A method for the synthesis of dihydrodibenzo[c,e]azocine derivatives via a regioselective intramolecular aminoiodination of alkynes under visible light irradiation has been developed. This protocol uses a combination of iodine and hypervalent iodine to re

A Rh(II)- or Ag(I)-Catalyzed Formal C-O Bond Insertion of Cyclic Hemiaminal with Aryl Diazoacetate

A mild and facile synthetic method via convergent assembly of two reactive intermediates generated in situ has been developed. This method provides an efficient way to construct six- and sevenmembered N-heterocycles containing a biaryl linkage. This react

Nickel-catalyzed asymmetric intramolecular reductive heck reaction of unactivated alkenes

An asymmetric Ni-catalyzed intramolecular reductive Heck reaction of unactivated alkenes tethered to aryl bromides has been accomplished, providing a variety of benzene-fused cyclic compounds bearing a quaternary stereogenic center in good to excellent yi

Visible-light, iodine-promoted formation of n-sulfonyl imines and n-alkylsulfonamides from aldehydes and hypervalent iodine reagents

Alternative synthetic methodology for the direct installation of sulfonamide functionality is a highly desirable goal within the domain of drug discovery and development. The formation of synthetically valuable N-sulfonyl imines from a range of aldehydes,

Direct Sulfonamidation of Primary and Secondary Benzylic Alcohols Catalyzed by a Boronic Acid/Oxalic Acid System

The direct sulfonamidation of primary and secondary benzylic alcohols catalyzed by a 2,3,4,5-tetrafluorophenylboronic acid/oxalic acid co-catalytic system was examined. The reaction proceeds under mild conditions with readily available starting materials and has been shown to be gram-scalable without significant decrease of yield. Both primary and secondary benzylic alcohols were evaluated and afforded the desired sulfonamide products with good to excellent yields.

Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines

A simple and convenient method has been developed for the construction of sulfonamides via I2O5-mediated sulfonylation of amines with arylthiols. The present protocol provides an attractive approach to sulfonamides in moderate to good yields from readily accessible and easy to handle starting materials under mild and metal-free conditions.

Preparation method of sulfonamides compound

The invention discloses a reparation method of a sulfonamides compound. The preparation method includes: using thiophenol and amine which are simple and easy to get as raw materials; enabling the raw materials to be in direct oxidation coupling reaction under mediation of safe and stable iodine pentoxide to prepare sulfonamide. The preparation method has the advantages that reaction conditions are mild (60 DEG C), the raw materials are simple and easy to get and low in price, reaction environment is friendly, a substrate is wide in application range, and metal catalysts and harsh reaction conditions like low or high temperature and zero water and zero oxygen are not needed, so that metal pollution related to common synthesis methods is avoided; the preparation method further has the advantages of simple, convenient and safe operation, stable process condition and easiness in product purification and is suitable for large-scale production.

Atmosphere- and Temperature-Controlled Regioselective Aminobromination of Olefins

A complete switch of regioselectivity in the aminobromination of olefins is realized from delicate changes in the reaction temperature from 25 °C to 40 °C and the atmosphere from air to argon, under catalyst-free conditions. The resulting α-bromoamides ca

Trapping σ-Alkyl–Palladium(II) Intermediates with Arynes Encompassing Intramolecular C?H Activation: Spirobiaryls through Pd-Catalyzed Cascade Reactions

A palladium-catalyzed cascade reaction based on the trapping of transient alkyl–PdIIintermediates with arynes encompassing a C?H activation step has been developed. This synthetic pathway gives rise to hetero-spirocyclic scaffolds containing a biaryl motif, and opens up new synthetic strategies in the design of cascade reactions since it gathers several aspects of Pd chemistry, i.e., intra- and intermolecular carbopalladation of unsaturated species, C?H activation and C?C coupling processes.