328258-73-7Relevant academic research and scientific papers
Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities
Huang, Wei,Sun, Xihuan,Li, Yunzhan,He, Zhixiang,Li, Li,Deng, Zhou,Huang, Xiaoxing,Han, Shang,Zhang, Ting,Zhong, Jiaji,Wang, Zheng,Xu, Qingyan,Zhang, Jianming,Deng, Xianming
supporting information, p. 5424 - 5434 (2018/06/18)
Methuosis is a novel nonapoptotic mode of cell death characterized by vacuole accumulation in the cytoplasm. In this article, we describe a series of azaindole-based compounds that cause vacuolization in MDA-MB-231 cells. The most potent vacuole inducer,
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II
Zhang, Guobao,Ren, Pingda,Gray, Nathanael S.,Sim, Taebo,Wang, Xia,Liu, Yi,Che, Jianwei,Dong, Weitong,Tian, Shin-Shay,Sandberg, Mark L.,Spalding, Tracy A.,Romeo, Russell,Iskandar, Maya,Wang, Zhiliang,Seidel, H. Martin,Karanewsky, Donald S.,He, Yun
scheme or table, p. 6691 - 6695 (2010/06/12)
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src-family kinases (SFKs). These type II inhibitors were optimized using a cellular Lck-dependent proliferation assay and are
