328259-21-8

Basic information

• Product Name: N-ethyl-2-nitro-N-phenylbenzamide
• Synonyms: N-ethyl-2-nitro-N-phenylbenzamide
• CAS NO: 328259-21-8
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.28326
• Mol File: 328259-21-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-ethyl-2-nitro-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-2-nitro-N-phenylbenzamide(328259-21-8)
• EPA Substance Registry System: N-ethyl-2-nitro-N-phenylbenzamide(328259-21-8)

Safety Data

• Hazardous Substances Data: 328259-21-8(Hazardous Substances Data)

Upstream product

• 2385-27-5 N-phenyl-2-nitrobenzamide 
• 75-03-6 ethyl iodide 
• 103-69-5 N-ethyl-N-phenylamine 
• 610-14-0 2-nitrobenzyl chloride 

Downstream Products

• 29094-86-8 anthranilic acid-(N-ethyl-anilide) 
• 102298-18-0 N-ethyl-N-(2-amino-benzyl)-aniline 

Relevant articles and documents

Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. Design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor

Although cyclooxygenase-1 (COX-1) inhibition is thought to be a major mechanism of gastric damage by nonsteroidal anti-inflammatory drugs (NSAIDs), some COX-1-selective inhibitors exhibit strong analgesic effects without causing gastric damage. However, it is not clear whether their analgesic effects are attributable to COX-1-inhibitory activity or other bioactivities. Here, we report that N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)benzamide (18f, TFAP), which has a structure clearly different from those of currently available COX-1-selective inhibitors, is a potent COX-1-selective inhibitor (COX-1 IC 50 = 0.80 ± 0.05 μM, COX-2 IC50 = 210 ± 10 μM). This compound causes little gastric damage in rats even at an oral dose of 300 mg/kg, though it has an analgesic effect at as low a dose as 10 mg/kg. Our results show that COX-1-selective inhibitors can be analgesic agents without causing gastric damage.