32847-25-9Relevant academic research and scientific papers
TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac
Babakov, Vladimir N.,Bardin, Alexander A.,Gorbunov, Alexander Yu.,Keltsieva, Olga A.,Krasnov, Konstantin A.,Podolskaya, Ekaterina P.
, p. 220 - 222 (2020/05/25)
The UV-induced photocatalytic oxidation in the presence of TiO2 nanoparticles (UV/TiO2-PCO) is a more adequate approach than electrochemical oxidation to simulate the oxidative metabolism of diclofenac based on the comparative analysis of oxidation products using high-resolution tandem mass spectrometry. A simple and fast high-throughput technique is proposed for modeling the oxidative metabolism, which involves UV/TiO2-PCO performed directly on a MALDI target and subsequent analysis by matrix-assisted laser desorption/ionization mass spectrometry. The ranges and yields of diclofenac oxidation products obtained by the conventional bulk UV/TiO2-PCO and the proposed on-target version are in excellent agreement.
Epoxy-epimination of cyclic conjugated dienes - VII. Cycloaddition of nitroso-halogenobenzenes to cyclopentadiene followed by rearrangement to epoxy-epimino- and γ-δ-epiminopentadienal derivatives via N-O and C-C bond breaking
Rouselle,Francotte,Feneau-Dupont,Tinant,Declercq,Viehe
, p. 8323 - 8330 (2007/10/02)
[4 + 2] Cycloaddition of halogenated nitroso benzenes to cyclopentadiene followed by isomerisation of the intermediated adduct occurs already at room temperature to furnish the epoxy-epimine 1 and the epiminopentadienal 2. The structure proof of 1 is based on X-ray analysis.
OXIDATION OF HYDRAZINES WITH NITROSOBENZENES
Kano, Kunio,Koga, Masahiro,Anselme, Jean-Pierre
, p. 137 - 144 (2007/10/02)
Nitrosoarenes react with 1,1-disubstituted hydrazines to yield products of direct oxidation and the thermally stable triazene N-oxides.The triazene N-oxides undergo photoinduced fragmentation to yield products which may be rationalized through the interme
Proximity Effects in Diaryl Derivatives. Part 7. Mechanism of Base-catalysed Rearrangement of 2-(Hydroxyamino)aryl Phenyl Sulphones to 2-Hydroxy-2'-(phenylsulphonyl)azoxybenzenes
Cummings, Robert J.,Grundon, Michael F.,Knipe, Anthony C.,Wasfi, Adil S.
, p. 105 - 108 (2007/10/02)
Base-catalysed rearrangement of a 2-(hydroxyamino)aryl phenyl sulphone (1b) to the 2-hydroxy-2'-(phenylsulphonyl)azoxybenzene (4b) was shown by isolation and kinetic studies to be a rapid reaction requiring oxygen; in the absence of oxygen the sulphur-free azoxybenzene (3; R=Cl) was the only product isolated from the reaction of (1c).A mechanism for the formation of 2-hydroxyazoxybenzenes (4) is proposed (Scheme 2) involving dimerization of a nitrosoaryl radical anion (9) to the dianion of an NN-diol (10), and displacement of a phenylsulphonyl group by intramolecular transfer of oxygen from a nitrogen atom.A similar study of the base-catalysed reactions of a 2-(hydroxyamino)aryl phenyl sulphide (12) in the presence of oxygen showed that with a poorer leaving group the bis(phenylthio)azoxybenzene (11; R=SPh) is formed.An improved procedure for the preparation of N-arylhydroxylamines from nitrobenzenes is described.
