32852-95-2Relevant articles and documents
HIGHLY REGIOSELECTIVE AROMATIC SUBSTITUTION ON A DIARYLOXIDETRICARBONYLCHROMIUM COMPLEX
Boutonnet, Jean-Charles,Rose-Munch, Francoise,Rose, Eric
, p. 3989 - 3992 (1985)
Ortho-substituted diaryloxide tricarbonylchromium (0) complexes PhOAr-Cr(CO)3, treated with carbanions Nu(-), give, after acid quenching, paradisubstituted complexes NuAr-Cr(CO)3 via a 1,3-hydride migration followed by elimination of phenol: the overall sequence of the reaction consists in a regioselective meta substitution of the phenoxy group by the nucleophile.
Method for synthesizing arylpropionic acid-like nonsteroidal antiinflammatory agent
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Paragraph 0037-0040, (2017/10/27)
The invention discloses a method for synthesizing an arylpropionic acid-like nonsteroidal antiinflammatory agent. The method comprises that an aryl acetonitrile compound as a substrate, an amine borane complex and N, N-dimethylformamide as a solvent undergo a methylation reaction under basic conditions to produce an aryl propionitrile compound, and the aryl propionitrile compound is hydrolyzed under strong basic conditions to form the arylpropionic acid-like nonsteroidal antiinflammatory agent. The method creatively uses the amine borane complex and N, N-dimethylformamide as methylation reagents so that bis-methylation and large toxicity caused by the traditional methylation reagents such as methyl iodide and dimethyl sulfate are avoided. The method is simple and is easy to operate. The arylpropionic acid-like nonsteroidal antiinflammatory agent has a high yield and high purity. Compared with the existing method using a metal catalyst system, the method utilizes anon-metallic system so that the use of transition metals is avoided. The method provides a novel approach for preventing metal residues in synthetic drugs.
Alpha-thio-alpha-aryl-substituted alkanonitrile and process for preparing alpha-aryl-substituted alkanonitrile therefrom
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, (2008/06/13)
An alpha-thio-alpha-aryl-substituted alkanonitrile of the general formula STR1 wherein Ar represents an aromatic group, R represents a hydrogen atom or an alkyl group, R1 represents an alkyl group or an aromatic group, and Y represents an oxygen atom or a carbonyl group. The above compound can be prepared by reacting an alpha-aryl-substituted-alpha-thio-acetonitrile of the general formula STR2 wherein Ar, Y and R1 are as defined above, with an alkylating agent in the presence of a strong base. This compound is useful as an intermediate for producing an alpha-aryl-substituted alkane-carboxylic acid of the general formula STR3 wherein Ar, Y and R1 are as defined above.