32852-93-0Relevant academic research and scientific papers
A new convenient reduction of aralkyl ketones to alcohols using Raney nickel-ammonium formate
Chen,Zhang,Yuan,Zhang
, p. 107 - 109 (1991)
Various aralkyl ketones have been reduced to their corresponding alcohols in high yield using Raney Ni-HCO2NH4.
Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem-Difluoroalkenes with Carbon Electrophiles by C?F Bond Activation
Zhu, Ziqi,Lin, Lin,Xiao, Jieshuai,Shi, Zhuangzhi
supporting information, (2021/12/27)
Stereo- and enantioselective cross-electrophile coupling involving C?F bond activation is reported. Treatment of gem-difluoroalkenes with racemic benzyl electrophiles in the presence of a chiral nickel complex using B2pin2 as a stoichiometric reductant allows the construction of a C(sp2)?C(sp3) bond under mild conditions, affording a broad range of monofluoroalkenes bearing stereogenic allylic centers. Initial mechanistic studies indicate that a radical chain pathway may be operating, wherein the ester group in the gem-difluoroalkene promotes C?F bond activation through oxidative addition to a Ni species.
Novel method for high-yield preparation of roxadustat intermediate
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Paragraph 0046-0049, (2021/08/14)
The invention discloses a preparation method of a roxadustat intermediate. The preparation method comprises the following steps: (1) subjecting a compound 1 and a compound 2 to reacting in an organic solvent under the catalysis of alkali to obtain an intermediate 3; (2) reducing the intermediate 3 in an organic solvent through a reducing agent to obtain an intermediate 4; (3) subjecting the intermediate 4 to reacting with a bromination reagent in an organic solvent to obtain an intermediate 5; (4) subjecting the intermediate 5 to reacting with a compound 6 in an organic solvent under the catalysis of acid to obtain an intermediate 7; (5) carrying out a cyclization reaction on the intermediate 7 in an organic solvent and a catalytic system to prepare an intermediate 8; and (6) subjecting the intermediate 8 to reacting in an organic solvent through a dehydrogenation reagent to obtain the roxadustat intermediate 9. The preparation method of the roxadustat intermediate has the advantages that raw materials are easy to obtain, operation steps are few, a process is simple, reaction yield is high, an atom utilization rate is high, and industrial production is easy.
RECEPTOR FUNCTION REGULATING AGENT
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Page/Page column 94, (2010/11/23)
An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
