32889-17-1Relevant academic research and scientific papers
Asymmetric Hydrogenation of Seven-Membered C=N-containing Heterocycles and Rationalization of the Enantioselectivity
Balakrishna, Bugga,Bauzá, Antonio,Frontera, Antonio,Vidal-Ferran, Anton
supporting information, p. 10607 - 10613 (2016/07/21)
Iridium(I) complexes with phosphine–phosphite ligands efficiently catalyze the enantioselective hydrogenation of diverse seven-membered C=N-containing heterocyclic compounds (eleven examples; up to 97 % ee). The P-OP ligand L3, which incorporates an ortho
Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations
Baumann, Marcus,Baxendale, Ian R.,Hornung, Christian H.,Ley, Steven V.,Rojo, Maria Victoria,Roper, Kimberley A.
, p. 9736 - 9759 (2014/08/05)
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.
An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation
Wang, Xiao-Jian,Tian, Yu-Lin,Zhang, Qing-Yang,Qi, Jian-Guo,Yin, Da-Li
, p. 743 - 746 (2013/07/26)
An efficient synthesis of substituted 1,4-diazepines is developed. The accessible intermediates have been obtained via Pd-catalyzed amination. The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one po
Concise palladium-catalyzed synthesis of dibenzodiazepines and structural analogues
Tsvelikhovsky, Dmitry,Buchwald, Stephen L.
, p. 14228 - 14231 (2011/10/31)
A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.
