3289-38-1

Basic information

• Product Name: 4-Amino-6-chloro-2-diethylaminopyrimidine
• Synonyms: 4-Amino-6-chloro-2-diethylaminopyrimidine;6-chloro-N~2~,N~2~-diethyl-2,4-pyrimidinediamine(SALTDATA: FREE);6-chloro-N~2~,N~2~-diethyl-2,4-pyrimidinediamine
• CAS NO: 3289-38-1
• Molecular Formula: C8H13ClN4
• Molecular Weight: 200.67
• Mol File: 3289-38-1.mol

Chemical Properties

• Boiling Point: 355.1 °C at 760 mmHg
• Flash Point: 168.6 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 3.19E-05mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 4-Amino-6-chloro-2-diethylaminopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-6-chloro-2-diethylaminopyrimidine(3289-38-1)
• EPA Substance Registry System: 4-Amino-6-chloro-2-diethylaminopyrimidine(3289-38-1)

Safety Data

• Hazardous Substances Data: 3289-38-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-6-chloro-2-diethylaminopyrimidine is used as a key intermediate for the synthesis of various drugs and agrochemicals. Its high reactivity allows for the creation of new compounds with potential therapeutic applications, contributing to the development of novel treatments for various diseases and conditions.
Used in Research and Development:
In the field of research and development, 4-Amino-6-chloro-2-diethylaminopyrimidine serves as an essential component in the creation of new compounds. Its unique properties and reactivity enable scientists to explore its potential in the discovery of innovative therapeutic agents, further advancing the field of medicinal chemistry.
Used in Organic Chemistry:
As a pyrimidine derivative, 4-Amino-6-chloro-2-diethylaminopyrimidine is a valuable building block in organic chemistry. It is utilized in the synthesis of a wide range of organic compounds, facilitating the development of new materials and chemical processes with diverse applications across various industries.

InChI:InChI=1/C8H13ClN4/c1-3-13(4-2)8-11-6(9)5-7(10)12-8/h5H,3-4H2,1-2H3,(H2,10,11,12)

Upstream product

• 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 
• 109-89-7 diethylamine 
• 100-46-9 benzylamine 
• 10132-07-7 4-amino-2,6-dichloropyrimidine 
• 74619-77-5 4-amino-6-chloro-2-methylsulphonylpyrimidine 
• 66380-47-0 4-amino-6-chloro-2-methylsulphinylpyrimidine 

Relevant articles and documents

A practical strategy for the synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines

Starting from commercially available 4-amino-2,6-dichloropyrimidine, a practical four steps synthesis of 2-dialkylamino-4-arylamino-6-aminopyrimidines was developed. This strategy could introduce a diverse set of secondary amines and arylamines to displac

Solid-phase synthesis of 2,4,6-triaminopyrimidines

Substituted pyrimidines are an important class of kinase inhibitors. We therefore developed a synthetic route suitable for the solid-phase synthesis of 2,4,6-triaminopyrimidines through displacement reactions on deactivated pyrimidines. Functionalising th

THE SYNTHESIS AND AMINOLYSIS OF SOME 4-CHLORO-2-(SUBSTITUTED)THIOPYRIMIDINES

Some 2-methylthio,2-methylsulphinyl and 2-methylsulphonyl-4-chloropyrimidines have been prepared.In each case which was studied except one the chloride ion was that which was preferentially displaced by diethylamine.The pseudo first order rate constant of for each reaction was determined the results showing that oxidation of the 2-methylthio group greatly enhances the rate of displacement of the 4-chloro group.