329-29-3Relevant academic research and scientific papers
Preparation of 1,1-difluoroalkanes from aldehydes via 1,1-bistriflates: Advantageous use of HF-Lewis base reagents
Dolbier, William R.,Okamoto, Masamune
, p. 96 - 100 (2015/03/05)
Alkane-1,1-bistriflates, prepared in excellent yields by reaction of aldehydes with triflic anhydride, are converted to their respective 1,1-difluoroalkanes in good to excellent yield through reaction with fluorinating agent, triethylaminetrishydrofluorid
Novel method for incorporating the CHF2 group into organic molecules using BrF3
Sasson, Revital,Hagooly, Aviv,Rozen, Shlomo
, p. 769 - 771 (2007/10/03)
(Matrix presented) 2-Alkyl-1,3-dithiane derivatives, easily made from alkyl bromides and the parent 1,3-dithiane, were reacted with BrF3 to form the corresponding 1,1-difluoromethyl alkanes (RCHF2) in 60-75% yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation. The two sulfur atoms of the dithiane are essential for the reaction.
Synthesis of 1,1-difluoroalkanes via phase transfer catalysed reaction of 1,1-bis-Triflates with KF in the presence of cocatalyst - Ph3SnF
Bujok, Robert,Makosza, Mieczys?aw
, p. 1285 - 1286 (2007/10/03)
1,1-bis-Triflates treated with KF in the presence of triphenyltin fluoride and tetrabutylammonium hydrogen sulfate give 1,1-difluoroalkanes.
A facile conversion of aliphatic aldehydes to 1,1-difluoroalkanes
Garcia Martinez,Osio Barcina,Rys,Subramanian
, p. 7787 - 7788 (2007/10/02)
Aliphatic aldehydes can be easily converted to 1,1-difluoroalkanes by reaction of the corresponding gem-bistriflates with tetrabutylammonium difluorotriphenylstannate.
The Generation of CF and an Investigation of the Products of Its Reaction with Alkenes
Rahman, M.,McKee, Michael L.,Shevlin, Philip B.
, p. 6296 - 6299 (2007/10/02)
The reaction of arc generated carbon atoms with CF4 at 77 K in the presence of alkene trapping agents results in the formation of fluorocyclopropanes and 1,1-difluoroalkanes.The fluorocyclopropanes are postulated to arise by addition of CF to the double bond generating a cyclopropyl radical which abstracts H.CF adds stereospecifically to olefins and gives both cis and trans fluorocyclopropanes with the trans generally predominating.The 1,1-difluoroalkanes are postulated to be the result of a 3CF2 reaction.In the presence of oxygen, the CF is oxidized to CO2, and the 3CF2 gives carbonyl fluoride.
