329020-64-6

Upstream product

• 661-69-8 hexamethyldistannane 
• 159217-89-7 N-Boc-4-iodoaniline 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 
• 1066-45-1 trimethyltin(IV)chloride 

Downstream Products

• 329020-70-4 2,5-Bis(4'-tert-butoxycarbonylaminophenyl)pyrazine 
• 3422-01-3 tert-butyl phenylcarbamate 
• 908580-99-4 methyl 5-{4-[(tert-butoxycarbonyl)amino]phenyl}-2-furoate 
• 910327-37-6 bis-(4-(tert-butoxycarbonylamino)phenyl)dimethylstannane 
• 59447-32-4 2,5-Bis(4'-aminophenyl)pyrazine 

Relevant academic research and scientific papers

Multifunctional Crown-5-calix[4]arene-based Phase-Transfer Catalysts for Aromatic 18F-Fluorination

Methylated bis-triethylene glycolic crown-5-calix[4]arene (M-BTC5A) as a phase-transfer catalyst showed the best performance among other analogues and even conventional Kryptofix 222 in the nucleophilic aromatic 18F-fluorination of diaryliodonium tosylate precursors owing to (i) the efficient release of reactive "naked"[18F]fluoride, (ii) the high stabilization of the precursor in the reaction, and, presumably, (iii) the ease of access between the precursor and the K18F/M-BTC5A complex facilitated by π-πinteractions. [18F]Flumazenil was produced in high radiochemical yield using M-BTC5A.

ARYL AMIDE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

On the reaction of 4-substituted trimethyltin aromatics with perchlorylfluoride

To evaluate the suitability of [18F]perchorylfluoride [18F]FClO3 as an electrophilic fluorination agent for the preparation of radiopharmaceuticals, the reactivity non-radioactive FClO3 towards 4-substituted trimethyltin aromatic compounds was studied. Contrary to the expectation, an electrophilic fluorination of the aromatic nucleus did not occur. The reaction of perchlorylfluoride with aromatic trimethylstannyl compounds resulted in the formation of trimethyltin fluoride and the respective destannylated aromatics in variable yields.

CHEMICAL COMPOUNDS

Compounds of formula (I) and their pharmaceutically acceptable salts are described: Formula (I). Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

Biphenyl substituted dipeptide analogs promote release of growth hormone

There are disclosed certain compounds identified as substituted dipeptide analogs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such substituted dipeptide analogs as the active ingredient thereof are also disclosed.