Organic Letters
Letter
precursor and the K18F/M-BTC5A complex probably facili-
tated by π−π interactions. It is notable that the PET
radiopharmaceutical [18F]FMZ was successfully prepared in
high RCY by the M-BTC5A-catalyzed nucleophilic aromatic
18F-fluorination protocol. These results suggest that this 18F-
labeling protocol using M-BTC5A has much potential in
radiopharmaceutical science.
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ASSOCIATED CONTENT
* Supporting Information
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The Supporting Information is available free of charge at
Experimental procedures and characterization data for
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AUTHOR INFORMATION
Corresponding Authors
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Byung Chul Lee − Department of Nuclear Medicine, Seoul
National University Hospital, Seongnam 13620, Republic of
Korea; Center for Nanomolecular Imaging and Innovative
Drug Development, Advanced institutes of Convergence
Technology, Suwon 16229, Republic of Korea; orcid.org/
Sang Eun Kim − Department of Nuclear Medicine, Seoul
National University Hospital, Seongnam 13620, Republic of
Korea; Center for Nanomolecular Imaging and Innovative
Drug Development, Advanced institutes of Convergence
Technology, Suwon 16229, Republic of Korea; Department of
Molecular and Biophamaceutical Sciences, Graduate School
of Convergence Science and Technology, Seoul National
University, Seoul 08826, Republic of Korea; Email: kse@
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Dong Wook Kim − Department of Chemistry and Chemical
Engineering, Inha University, Incheon 22212, Republic of
Authors
Won Chang Lee − Department of Nuclear Medicine, Seoul
National University Hospital, Seongnam 13620, Republic of
Korea; Department of Transdisciplinary Studies, Graduate
School of Convergence Science and Technology, Seoul
National University, Seoul 08826, Republic of Korea
Seok Min Kang − Department of Chemistry and Chemical
Engineering, Inha University, Incheon 22212, Republic of
Korea.
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Chi, D. Y.; Song, C. E. Angew. Chem., Int. Ed. 2009, 48, 7683−7686.
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2012, 18, 3918−3924.
Complete contact information is available at:
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E.; Kim, D. W. Tetrahedron 2013, 69, 3577−3583.
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Notes
The authors declare no competing financial interest.
(30) Taher, A.; Lee, K. C.; Han, H. J.; Kim, D. W. Org. Lett. 2017,
19, 3342−3345.
ACKNOWLEDGMENTS
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This work was supported by a grant from the Korean Health
Technology R&D Project through the Korean Health Industry
Development Institute (KHIDI), funded by the Ministry of
Health & Welfare, Republic of Korea (no. HI16C0947).
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