32909-74-3

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3,4-Tetrahydro-isoquinoline-1-carboxylic acid methyl ester is used as a potential pharmaceutical compound for its structural similarity to naturally occurring alkaloids, which may contribute to its potential bioactivity. Its application in this industry is aimed at exploring its possible use in the development of new drugs or therapeutic agents. Further research is necessary to understand its full potential and to harness its properties for medicinal purposes.

Upstream product

• 67-56-1 methanol 
• 41034-52-0 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

Downstream Products

• 15987-50-5 1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one 
• 135526-78-2 (-)-Praziquantel 
• 55375-92-3 (R)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one 
• 55375-96-7 C₁₇H₁₈N₂O 
• 92932-75-7 2-[(3-mercapto)-1-oxopropyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

Relevant academic research and scientific papers

Method for preparing (R)-praziquantel

The invention relates to a new method for preparing (R)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (R)-praziquantel

Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives

The synthesis of N-(3-mercaptopropionyl)-N-arylglycines (14a-x), -N-arylalanines (15a,b), -N-cycloalkylglycines (16a-k), and -1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids (17a-d), -1,2,3,4-tetrahydroquinoline-2-carboxylic acids (18a-f), and -indoline-2-carboxylic acids (19a-k) is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound, and the structure-activity relationship for each series is discussed. The in vivo inhibition of ACE and antihypertensive effects of representative compounds from each series are discussed. The most potent compound, 19d, had an in vitro ACE IC50 of 2.6 x 10-9 M and lowered blood pressure in spontaneous hypertensive rats 85 mm at a dose of 10 mg/kg po.

Substituted iminoacid derivatives, process for preparing them and their use as enzyme inhibitors

Bicyclic imino acids, particularly 2-carboxylic acid derivatives of azabicycloalkanes and process for preparing them. These compounds have therapeutical activity and may be used as medicines, particularly as cardiovascular and antihypertensive drugs in human or veterinary medicine.