32946-53-5

Basic information

• Product Name: N^im-trityl-L-histidine hydrochloride
• CAS NO: 32946-53-5
• Molecular Weight: 433.937
• Mol File: 32946-53-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^im-trityl-L-histidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N^im-trityl-L-histidine hydrochloride(32946-53-5)
• EPA Substance Registry System: N^im-trityl-L-histidine hydrochloride(32946-53-5)

Safety Data

• Hazardous Substances Data: 32946-53-5(Hazardous Substances Data)

Upstream product

• 74853-62-6 N^α,N^im-ditritylhistidine 
• 71-00-1 L-histidine 

Downstream Products

• 35146-32-8 2-amino-3-(N-tritylimidazolyl)propionic acid 
• 82882-70-0 N^α-tert-amyloxycarbonyl-N^im-tritylhistidine 
• 82882-71-1 N-α-carboxybenzyl-L-histidine N^im-trityl 
• 82882-72-2 N^α-4-methoxybenzyloxycarbonyl-N^im-tritylhistidine 
• 32926-43-5 N^α-(tert-butyloxy)carbonyl-N^im-triphenylmethyl-L-histidine 

Relevant articles and documents

IMPROVED METHODS OF OBTAINING Nim-TRITYL-SUBSTITUTED HISTIDINE DERIVATIVES

Two variants are proposed for the synthesis of Nα-Boc-Nim-tritylhistidiine.The first variant starts from Nα,Nim-di-Boc-histidine, from which the Nim-Boc group is removed with hydrazine hydrate.The Nα-Boc-histidine formed is esterified with chlorotrimethylsilane, tritylated in the imidazole group, and, after the elimination of the trimethylsilyl protection from the carboxyl group, Nα-Boc-Nim-tritylglycine is obtained with a yield of 80percent.The second variant starts from Nα,Nim-ditritylhistidine, which, by treatment with hydrochloric acid in acetone and then with dilute ammonia, is converted into Nim- tritylhistidine.From this, by acylation with di-tert-butyl pyrocarbonate, Nα-Boc-Nim-tritylhistidine is obtained with a yield of 91percent.The acylation of Nim-tritylhistidine with other alkoxycarbonylating reagents leads to Nα-tert-amyl-, Nα-benzyl-, and Nα-4-methoxybenzyloxycarbonyl derivatives of Nim-tritylhistidine.