35146-32-8

Basic information

• Product Name: H-HIS(TRT)-OH
• Synonyms: H-L-HIS(TRT)-OH;HISTIDINE(1-TRT)-OH;H-HIS(1-TRT)-OH;H-HIS(T-TRT)-OH;H-HIS(TRT)-OH;RARECHEM AL BE 1480;N-IM-TRITYL-HISTIDINE;N-IM-TRITYL-L-HISTIDINE
• CAS NO: 35146-32-8
• Molecular Formula: C₂₅H₂₃N₃O₂
• Molecular Weight: 397.47
• EINECS: 1308068-626-2
• Product Categories: Histidine [His, H];Amino Acids and Derivatives;Amino Acid Derivatives;Histidine;Peptide Synthesis
• Mol File: 35146-32-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 210℃
• Boiling Point: 584.8 °C at 760 mmHg
• Flash Point: 307.5 °C
• Appearance: /Solid
• Density: 1.19 g/cm³
• Vapor Pressure: 1.62E-14mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: −20°C
• PKA: 1.78±0.10(Predicted)
• CAS DataBase Reference: H-HIS(TRT)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-HIS(TRT)-OH(35146-32-8)
• EPA Substance Registry System: H-HIS(TRT)-OH(35146-32-8)

Safety Data

• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 35146-32-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

1-(Triphenylmethyl)-L-histidine is a reactant in the synthesis of falcitidin acyl tetrapeptides as antimalarial agent.

InChI:InChI=1/C25H23N3O2/c26-23(24(29)30)16-22-17-28(18-27-22)25(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17-18,23H,16,26H2,(H,29,30)/t23-/m0/s1

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 95383-91-8 L-Histidine 
• 76-83-5 trityl chloride 
• 74853-62-6 N^α,N^im-ditritylhistidine 
• 71-00-1 L-histidine 
• 71-00-1 L-histidine 
• 109425-51-6 Fmoc-His(Trt)-OH 
• 32946-53-5 N^im-trityl-L-histidine hydrochloride 
• 75-78-5 dimethylsilicon dichloride 

Downstream Products

• 109425-51-6 Fmoc-His(Trt)-OH 
• 1402572-88-6 PhSNPPOC-histidine(Trt)-OH 
• 71-00-1 L-histidine 
• 1333228-14-0 [{[(S)-1-Methylcarbamoyl-2-(1-trityl-1H-imidazol-4-yl)-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid methyl ester 
• 1333228-00-4 C₂₆H₂₆N₄O*CH₂O₂ 
• 888615-95-0 N^α-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecanoyl)-N^im-(trityl)histidine 
• 362043-68-3 TCP-His(Trt)-OH 

Relevant articles and documents

Preparation method of N - 9 - fluorenylmethoxycarbonyl - N ' - trityl - L - histidine

The invention relates to the technical field of medical intermediate synthesis, in particular to a synthetic method of N - 9 - fluorenylmethoxycarbonyl - N ' - trityl - L - histidine, which comprises the following steps: taking L - histidine as a raw material and protecting a - amino groups on histidine by using a silane protective agent. A silane protecting substance Nim - trityl histidine is obtained by reaction with triphenylchloromethane, followed by addition of water to the silane protecting group. The silane protecting substance Nim - trityl histidine is reacted with 9 - fluorenylmethoxycarbonyl protecting reagent to give the target product N - 9 - fluorenylmethoxycarbonyl - N ' - trityl - L - histidine. The N - 9 -fluorenylmethoxycarbonyl - N ' - trityl - L - histidine preparation method provided by the invention is simple and convenient to operate, high in yield and low in comprehensive production cost, and is suitable for industrial large-scale production.

Self-healing response in supramolecular polymers based on reversible zinc-histidine interactions

Histidine-metal interactions are utilized in many biological materials as reinforcing crosslinks, and in particular, are believed to contribute as reversible crosslinks to the intrinsic self-recovery behavior of mussel byssal threads. In this contribution

DIARYLSULPHID BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS

The present invention relates to photoactivable protecting groups containing a diarylsulphid chromophore, a method for the synthesis thereof and their use as photoactivable protecting groups using maskless photolithography based array synthesis. wherein R2 is [Formula II] or wherein R2 is [Formula III] or [Formula IV] wherein R7 is a natural amino acid, a non-natural amino acid or an amino acid derivative forming an urethan bond to formula Ib, or wherein formula IV represents the carboxy function of a natural amino acid, a non-natural amino acid or an amino acid derivative, forming an ester bond to formula Ib.