82882-71-1 Usage
Uses
Used in Pharmaceutical Production:
Boc-L-Histidine is used as a key intermediate in the synthesis of various pharmaceuticals due to its role as a derivative of the essential amino acid histidine. Its presence in the development of drugs highlights its importance in creating therapeutic agents that can target specific biological pathways.
Used in Peptide Synthesis:
In the field of peptide synthesis, Boc-L-Histidine serves as a crucial component, where the Boc protecting group allows for the stepwise assembly of peptide chains without unwanted side reactions. This contributes to the efficient and accurate construction of peptides with desired sequences and functions.
Used in Drug Research and Development:
Boc-L-Histidine is utilized as a valuable tool in the study and development of new drug molecules. Its unique structure and properties make it an attractive candidate for researchers looking to understand and manipulate biological systems, potentially leading to the discovery of innovative therapeutic agents.
Used in Biochemical Research:
In biochemical research, Boc-L-Histidine aids scientists in investigating the role of histidine in biological processes. L-Histidine, N-[(phenylmethoxy)carbonyl]-1-(triphenylmethyl)-'s protected structure allows for controlled experiments and a deeper understanding of the mechanisms involving histidine, which can be vital for developing targeted treatments and interventions.
Check Digit Verification of cas no
The CAS Registry Mumber 82882-71-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,8,8 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 82882-71:
(7*8)+(6*2)+(5*8)+(4*8)+(3*2)+(2*7)+(1*1)=161
161 % 10 = 1
So 82882-71-1 is a valid CAS Registry Number.
82882-71-1Relevant academic research and scientific papers
IMPROVED METHODS OF OBTAINING Nim-TRITYL-SUBSTITUTED HISTIDINE DERIVATIVES
Pozdnev, V. F.
, p. 322 - 327 (2007/10/02)
Two variants are proposed for the synthesis of Nα-Boc-Nim-tritylhistidiine.The first variant starts from Nα,Nim-di-Boc-histidine, from which the Nim-Boc group is removed with hydrazine hydrate.The Nα-Boc-histidine formed is esterified with chlorotrimethylsilane, tritylated in the imidazole group, and, after the elimination of the trimethylsilyl protection from the carboxyl group, Nα-Boc-Nim-tritylglycine is obtained with a yield of 80percent.The second variant starts from Nα,Nim-ditritylhistidine, which, by treatment with hydrochloric acid in acetone and then with dilute ammonia, is converted into Nim- tritylhistidine.From this, by acylation with di-tert-butyl pyrocarbonate, Nα-Boc-Nim-tritylhistidine is obtained with a yield of 91percent.The acylation of Nim-tritylhistidine with other alkoxycarbonylating reagents leads to Nα-tert-amyl-, Nα-benzyl-, and Nα-4-methoxybenzyloxycarbonyl derivatives of Nim-tritylhistidine.
