3296-03-5

Basic information

• Product Name: 3-Fluorophenyl azide solution
• Synonyms: 1-Azido-3-fluorobenzene solution;3-Fluorophenyl azide solution
• CAS NO: 3296-03-5
• Molecular Formula: C₆H₄FN₃
• Molecular Weight: 137.1144632
• Product Categories: Aromatic Azides;Azides;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 3296-03-5.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 31-32 °C(Press: 3 Torr)
• Flash Point: -33°C
• Appearance: /
• Density: 1.218 g/cm3
• Storage Temp.: ?20°C
• CAS DataBase Reference: 3-Fluorophenyl azide solution(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluorophenyl azide solution(3296-03-5)
• EPA Substance Registry System: 3-Fluorophenyl azide solution(3296-03-5)

Safety Data

• Hazard Codes: F,T
• Statements: 11-38-48/23/24/25
• Safety Statements: 16
• Hazardous Substances Data: 3296-03-5(Hazardous Substances Data)

Upstream product

• 2924-16-5 3-fluorophenylhydrazine hydrochloride 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 372-19-0 meta-fluoroaniline 
• 455-68-5 methyl 3-fluorobenzoate 
• 20893-73-6 3-fluorophenyldiazonium chloride 
• 1996-38-9 3-fluorobenzenediazonium tetrafluoroborate 

Downstream Products

• 1185251-57-3 methyl 1-(3-fluorophenyl)-1H-1,2,3-triazole-4-carboxylate 
• 1026185-48-7 N-((tert-butylimino)methylene)-3-fluoroaniline 

Relevant articles and documents

Novel 1,2,3-triazole derivatives as mimics of steroidal system—synthesis, crystal structures determination, hirshfeld surfaces analysis and molecular docking

Herein, we present the synthesis and crystal structures determination of five 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives containing halogen atoms, 6a–e, which may be used as an excellent mimic of steroids in the drug development process. Good qu

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives

In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol