49827-44-3

Usage

Physical state

Colorless, flammable liquid.

Odor

Fruity.

Usage in food industry

Commonly used as a flavoring agent.

Industrial applications

Used as a solvent in various processes, and as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Other applications

Production of fragrances, polymers, and plasticizers.

Toxicity

Low toxicity, but exposure to high concentrations may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H14O4/c1-8(2,7(10)12-4)5-6(9)11-3/h5H2,1-4H3

Upstream product

• 49827-35-2 Sodium; 3-tert-butylsulfanyl-3-methoxycarbonyl-butyrate 
• 74-88-4 methyl iodide 
• 547-63-7 Methyl isobutyrate 
• 96-32-2 bromoacetic acid methyl ester 
• 597-43-3 2,2-dimethylsuccinic acid 
• 75-36-5 acetyl chloride 
• 186581-53-3 diazomethane 
• 32501-16-9 1-Acetyl-3,3-dimethylcyclohexa-1,4-diene 
• 67-56-1 methanol 

Downstream Products

• 144782-34-3 (E)-3-p-Tolyl-but-2-enoic acid diisopropylamide 
• 144782-31-0 2,2-Dimethyl-3-((E)-3-p-tolyl-but-2-enoyl)-succinic acid dimethyl ester 
• 144782-26-3 dimethyl 2,2-dimethyl-3-benzylsuccinate 
• 102696-77-5 3-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-2,2-dimethyl-succinic acid 4-methyl ester 
• 102696-81-1 3-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-2,2-dimethyl-succinic acid 4-methyl ester 
• 2806-66-8 α,α-Dimethyl-bernsteinsaeure-α(oder β)-methyl-<4-nitro-anilid> 
• 144782-33-2 2,2-Dimethyl-4-oxo-6-p-tolyl-heptanoic acid 
• 144782-32-1 (E)-2,2-Dimethyl-4-oxo-6-p-tolyl-hept-5-enoic acid 
• 144782-27-4 2,2-dimethyl-3-benzylsuccinic acid 
• 102779-85-1 3-[1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-2,2-dimethyl-succinic acid 
• 102696-85-5 3-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-2,2-dimethyl-succinic acid 
• 102696-87-7 3-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-2,2-dimethyl-succinic acid 
• 102696-92-4 4-[1-(2-Methoxy-phenyl)-meth-(E)-ylidene]-3,3-dimethyl-dihydro-furan-2,5-dione 
• 102696-88-8 3-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-2,2-dimethyl-succinic acid 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS

Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.

NOVEL OXATHIOLANE CARBOXYLIC ACIDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Lewis base catalyzed Michael reaction between ketene silyl acetals and α,β-unsaturated carbonyl compounds

Catalytic Michael reaction between trimethylsilyl enolates and α,β-unsaturated carbonyl compounds by using a Lewis base such as lithium benzamide or lithium succimide in a DMF solvent proceeded smoothly to afford the corresponding Michael adducts.

2,2-Dimethylsuccinic acid derivatives in isoprenoid synthesis: a 2,2-dimethylvinyl anion equivalent in the synthesis of ar-atlantone, ar-turmerone, and prenylated aromatic compounds

The anion of methyl 2,2-dimethylsuccinate was alkylated with benzylic bromides to give the corresponding 3-substituted-2,2-dimethylsuccinates.Hydrolysis to the dicarboxylic acids, followed by bisdecarboxylation with lead tetraacetate, afforded 1-aryl-3-methyl-2-butenes, which are model prenylated aromatic compounds.Acylation of methyl-2,2-dimethylsuccinate with E-3-(4'-methylphenyl)crotonyl chloride gave the substituted succinate 9.Hydrolysis of the ester groups and acid-catalyzed decarboxylation of the resulting β-ketoacid produced the keto acid 10, which was decarboxylated by the Kochi method, furnishing ar-atlantone.Hydrogenatio n of 10 yielded 12, which on similar decarboxylation afforded ar-turmerone.