329907-54-2Relevant academic research and scientific papers
Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists
Ladouceur, Gaetan H.,Cook, James H.,Doherty, Elizabeth M.,Schoen, William R.,MacDougall, Margit L.,Livingston, James N.
, p. 461 - 464 (2007/10/03)
5-Hydroxyalkyl-4-phenylpyridines have been identified as a novel class of glucagon antagonists with potential utility for the treatment of diabetes. A lead structure with moderate activity was discovered through a high throughput screening assay. Structure-activity relationships led to the discovery of a potent antagonist, IC50=0.11 μM, more than 60-fold improvement over the lead structure.
