33021-17-9Relevant academic research and scientific papers
Synthesis of substrate analogues as potential inhibitors for Mycobacterium tuberculosis enzyme MshC
Patel, Krishnakant,Song, Fengling,Andreana, Peter R.
, p. 10 - 18 (2017/11/07)
Mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis and a promising target for developing new anti-mycobacterial compounds. Herein, we report on the synthesis of substrate analogues, as potential inhibitors, for the MshC e
Synthesis of high-performance polyurethanes with rigid 5-6-5-fused ring system in the main chain from naturally occurring myo-inositol
Sudo, Atsushi,Shibata, Yoshiya,Miyamoto, Ayano
, p. 3956 - 3963 (2013/09/02)
A bisketal of myo-inositol was used as a diol-type monomer for synthesis of polyurethanes. The monomer was obtained by treatment of myo-inositol with 1,1-dimethoxycyclohexane in the presence of p-toluenesulfonic acid as a catalyst. The ketalization resulted in the formation of a 5-6-5-fused ring system, which endowed the diol-type monomer with high rigidity. The diol readily reacted with diisocyanate to give the corresponding polyurethane, which exhibited excellent heat resistance due to the rigid 5-6-5 system in the main chain. Copyright
H2SO4-silica: An eco-friendly heterogeneous catalyst for the differential protection of myo-inositol hydroxyl groups
Vibhute, Amol M.,Sureshan, Kana M.
, p. 7321 - 7329 (2013/07/05)
There is enormous interest in myo-inositol derivatives as they serve as precursors for the synthesis of several biologically important phosphoinositols, natural products, catalyst, supramolecular architectures etc. However the presence of six secondary hy
Inositol-phosphate derivatives and method of detecting inositol-1-phosphate
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Page/Page column 38, (2012/05/20)
The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule
Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains
Swarts, Benjamin M.,Guo, Zhongwu
scheme or table, p. 6648 - 6650 (2010/07/04)
A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.
First Total Synthesis of Mycothiol and Mycothiol Disulfide
Lee, Sungwon,Rosazza, John P. N.
, p. 365 - 368 (2007/10/03)
(Matrix presented) The first total synthesis of mycothiol and mycothiol disulfide was achieved by linking D-2,3,4,5,6-penta-O-acetyl-myo-inositol, O-(3,4,6-tri-O-acetyl)-2-azido-2-deoxy-α,β-D-glucopyranosyl) trichloroacetimidate, and N,S-diacetyl-L-cysteine and deprotecting peracetylated mycothiol. The first full spectral characterization is reported for underivatized mycothiol. The structure of mycothiol was confirmed by spectral analysis of the known bimane derivative.
First total synthesis of a GPI-anchored peptide
Xue, Jie,Shao, Ning,Guo, Zhongwu
, p. 4020 - 4029 (2007/10/03)
A GPI-anchored dipeptide of sperm CD52 antigen was prepared through a convergent synthesis. First, the dipeptide with its C-terminus free and the GPI with its nonreducing end phosphoeth-anolamine bearing a free amino group were synthesized separately. Then, the two building blocks were coupled with use of EDC/HOBt as the condensation reagent. Finally, the GPI-anchored peptide was deprotected to give the target molecule 1.
Modulation of the inositol 1,4,5-trisphosphate receptor by inositol phosphates
Lu, Pei-Jung,Chen, Ching-Shih
, p. 325 - 328 (2007/10/03)
The mode of recognition at the binding site of the Ins(1,4,5)P3 receptor was assessed by examining the structure-activity relationships of different Ca2+-mobilizing inositol phosphates.
Synthesis of meso-cyclohexa-3,5-diene-1,2-diol derivative from myo-inositol
Mereyala, Hari Babu,Pannala, Madhavi
, p. 2121 - 2124 (2007/10/02)
Synthesis of (meso)1,2-O-cyclohexylidene-cyclohexa-3,4-diene (4) in four steps from myo-inositol and its exclusive conversion to the vinylic epoxide 13 is described.
SYNTHESIS, POTENTIOMETRIC AND 31P-NMR INVESTIGATIONS OF THE IONIZATION STATE AND COMPLEXATION PROPERTIES OF INOSITOL-PHOSPHATES: BIOLOGICAL CONSEQUENCES
Schmitt, Laurent,Bortmann, Patrick,Spiess, Bernard,Schlewer, Gilbert
, p. 147 - 150 (2007/10/02)
The synthesis and the potentiometric studies of inositol-phosphates allow, particularly for Ins(1,4,5)P3, the correlation between the ionization state of the phosphate functions and the binding properties of the inositol-phosphates.
