33026-77-6

Basic information

• Product Name: 1-(benzyloxy)-3-phenylurea
• Synonyms: 1-(Benzyloxy)-3-phenylurea; urea, N-phenyl-N'-(phenylmethoxy)-
• CAS NO: 33026-77-6
• Molecular Formula: C₁₄H₁₄N₂O₂
• Molecular Weight: 242.2732
• Mol File: 33026-77-6.mol
• Article Data: 8

Chemical Properties

• Density: 1.221g/cm³
• Refractive Index: 1.627
• CAS DataBase Reference: 1-(benzyloxy)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-3-phenylurea(33026-77-6)
• EPA Substance Registry System: 1-(benzyloxy)-3-phenylurea(33026-77-6)

Safety Data

• Hazardous Substances Data: 33026-77-6(Hazardous Substances Data)

Usage

General Description

1-(benzyloxy)-3-phenylurea is a chemical compound consisting of a phenylurea group (a carbamate derivative) and a benzyloxy group attached to the nitrogen atom. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. The benzyloxy group is known for its ability to enhance the bioavailability and lipophilicity of the compound, making it suitable for drug development. Additionally, the phenylurea group imparts stability and reactivity to the molecule, making it a versatile building block for organic synthesis. The compound has potential applications in the development of drugs for various therapeutic areas such as cancer, inflammation, and infectious diseases.

Upstream product

• 622-33-3 N-benzyloxyamine 
• 103-71-9 phenyl isocyanate 
• 62-53-3 aniline 
• 83948-52-1 1-(4-nitrophenol)-N-(O-benzylhydroxy) carbamate 
• 92289-72-0 imidazole-1-carboxylic acid benzyloxyamide 

Downstream Products

• 53821-10-6 1-(benzyloxy)-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 86690-36-0 1-(benzyloxy)-3-methyl-1H-benzo[d]imidazol-2(3H)-one 
• 53821-11-7 1-hydroxy-1H-benzo[d]imidazol-2(3H)-one 
• 7335-35-5 1-hydroxy-3-phenylurea 
• 622-33-3 N-benzyloxyamine 
• 1007-36-9 1-methyl-3-phenylurea 

Relevant articles and documents

Vinylogous Aza-Michael Addition of Urea Derivatives with p-Quinone Methides Followed by Oxidative Dearomative Cyclization: Approach to Spiroimidazolidinone Derivatives

Herein, we report an efficient protocol for the synthesis of spiro-imidazolidinone-cyclohexadienones from p-quinone methides (p-QMs) and dialkyloxy ureas under mild conditions. The strategy follows a two-step process involving an initial vinylogous conjugate addition of urea derivatives to p-QMs, followed by oxidative dearomative cyclization of open-chain product to the projected spiro-imidazolidinones. This protocol exhibits good functional group tolerance and provides a straightforward method to access spiro-imidazolidinone-cyclohexadienones. In follow-up chemistry, we have shown the debenzylation of spiroimidazolidinones to give N-hydroxycyclic ureas. (Figure presented.).

Synthesis and SAR of 1-hydroxy-1 H -benzo[ d ]imidazol-2(3 H)-ones as inhibitors of d -amino acid oxidase

A series of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones were synthesized and evaluated for their ability to inhibit human and porcine forms of d-amino acid oxidase (DAAO). The inhibitory potency is largely dependent on the size and position of substituents o

N-substituted hydroxyureas as urease inhibitors

In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl-(10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.