131666-63-2

Upstream product

• 890050-54-1 3-hydroxy-4-triphenylmethoxybutanenitrile 
• 108-05-4 vinyl acetate 
• 126577-60-4 (3S)-3,4-dihydroxybutyronitrile 
• 76-83-5 trityl chloride 

Downstream Products

• 113240-55-4 ethyl (S)-5-hydroxy-3-oxo-6-(triphenylmethoxy)hexanoate 
• 113240-61-2 1,1-Dimethylethyl (S)-5-hydroxy-3-oxo-6-(triphenylmethoxy)hexanoate 
• 330555-58-3 (S)-3-hydroxy-4-triphenylmethoxybutanamide 

Relevant academic research and scientific papers

Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB

Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alcohol and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified cera

Process for the production of 3,5,6-trihydroxyhexanoic acid derivative

A compound of a 3,5,6-trihydroxyhexanoic acid derivative of the formula: STR1 wherein P1 and P2 are independently hydrogen atoms or hydroxy-protecting groups, or together form a ring, and R is an alkyl group is effectively prepared by a process comprising steps of: reacting a butyronitrile derivative of the formula: STR2 wherein P1 and P2 are the same as defined above with an α-haloacetate of the formula: wherein X is a halogen atom, and R is the same as defined above in the presence of a metallic catalyst selected from the group consisting zinc and zinc-copper to form a keto acid derivative of the formula: STR3 wherein P1, P2 and R are the same as defined above, and then reducing the obtained keto-acid derivative of the formula (IV).