33077-70-2

Usage

InChI:InChI=1/C12H9NO2/c14-10-6-4-9(5-7-10)12(15)11-3-1-2-8-13-11/h1-8,14H

Upstream product

• 29745-44-6 pyridine-2-carbonyl chloride 
• 98-98-6 2-Picolinic acid 
• 5029-67-4 2-iodopyridine 
• 99-96-7 4-hydroxy-benzoic acid 
• 6305-18-6 2-(4-methoxybenzoyl)pyridine 
• 26838-86-8 pyridine-2-carboxylic acid phenyl ester 

Downstream Products

• 21464-88-0 4-(5,5-diphenyl-2-pyridin-2-yl-[1,3]dioxan-2-yl)-phenol 
• 1231922-04-5 (4-(3-chloropyrazin-2-yloxy)phenyl)(pyridin-2-yl)methanone 
• 1231923-83-3 Pyridin-2-yl(4-(3-(tetrahydro-2H-pyran-4-yl)pyridin-2-yloxy)phenyl)methanone 
• 21464-43-7 4-(5,5-diphenyl-2-piperidin-2-yl-[1,3]dioxan-2-yl)-phenol 
• 603-50-9 bisacodyl 
• 603-41-8 4,4'-(2-pyridylmethylene)diphenol 

Relevant academic research and scientific papers

The light-emitting compound and use this light-emitting compound of the organic light emitting diode device

An embodiment of the present invention provides an emitting compound of following formula: wherein “A” is represented by and “B” is represented by

A Nitrogen-Assisted One-Pot Heteroaryl Ketone Synthesis from Carboxylic Acids and Heteroaryl Halides

A practical and highly effective one-pot synthesis of versatile heteroaryl ketones directly from carboxylic acids and heteroaryl halides under mild conditions is reported. This method does not require derivatization of carboxylic acids (preparation of acid chlorides, Weinreb amides, etc.) or the use of any additives/catalysts. A wide substrate scope of carboxylic acids with high functional group tolerance has also been demonstrated. The results reveal that the presence of an α-nitrogen on the halide substrate greatly improves the desired ketone formation.

AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS

Pyridine and pyrimidine compounds: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification; or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification; and or a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification; compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Synthesis of triphenylmethane derivative: Bisacodyl

A new method for the synthesis of bisacodyl 1 is described. The key step involves migration of 2-pyridacyl group of phenyl pyridine-2-carboxylate 4 in AlCl3 at 160 °C to yield the intermediate 4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO 4 gives 1. This method has advantage over the existing literature methods because easily available pyridine-2-carboxylic acid is used as a starting material instead of the less stable pyridine-2-carboxaldehyde.