330785-99-4

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester
• Synonyms: 2-hydroxy-5-ethoxycarbonyl-4-(3-chloro-4-methoxybenzylamino)pyrimidine
• CAS NO: 330785-99-4
• Molecular Formula: C15H16ClN3O4
• Molecular Weight: 337.763
• Mol File: 330785-99-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester(330785-99-4)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1,2-dihydro-2-oxo-, ethyl ester(330785-99-4)

Safety Data

• Hazardous Substances Data: 330785-99-4(Hazardous Substances Data)

Usage

Uses

Ethyl 4-((3-Chloro-4-methoxybenzyl)amino)-2-hydroxypyrimidine-5-carboxylate is an Avanafil related substance. Avanafil is a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction.

Upstream product

• 330785-82-5 4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonyl-2-methylsulfinylpyrimidine 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 115514-77-7 (3-chloro-4-methoxyphenyl)methanamine 
• 330785-81-4 ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 586-98-1 2-Hydroxymethylpyridine 
• 372117-76-5 2-methylsulfonyl-5-ethoxycarbonyl-4-(3-chloro-4-methoxybenzylamino)pyrimidine 

Downstream Products

• 330786-00-0 2-chloro-4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonylpyrimidine 
• 1638497-22-9 ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate 
• 330785-84-7 4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid 

Relevant articles and documents

A arab league cuts down that non-intermediate the refined purification method

The invention provides a non-intermediate arab league cuts down that the refined purification method, it mainly utilizes arab league cuts down that non-intermediate 4 - [(3 - chloro - 4 - methoxyphenyl) methylamino] - 2 - [(S)- 2 - hydroxy methyl pyrrole

The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

Novel pyrimidine-5-carboxamide derivatives bearing a 3-chloro-4-methoxybenzylamino group at the 4-position were identified as potent and highly selective phosphodiesterase 5 inhibitors. Among them, we successfully found 10j (avanafil) which exhibited a potent relaxant effect on isolated rabbit cavernosum (EC30 = 2.1 nM) and a high isozyme selectivity.

Aromatic nitrogen-containing 6-membered cyclic compounds

An aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lower alkyl group, —NH—Q—R3 (R3 is a substituted or unsubstituted nitrogen containing heterocyclic group, and Q is a lower alkylene group or a single bond), or —NH—R4 (R4 is a substituted or unsubstituted cycloalkyl group); R2 is a substituted or unsubstituted aryl group; one of Y and Z is ═CH—, and the other is ═N—, or a pharmaceutically acceptable salt thereof, these compounds exhibiting excellent selective PDE V inhibitory activities, and hence, being useful in the prophylaxis or treatment of penile erectile dysfunction, etc.