3308-39-2Relevant academic research and scientific papers
Catalytic Oxidative Deamination by Water with H2Liberation
Tang, Shan,Rauch, Michael,Montag, Michael,Diskin-Posner, Yael,Ben-David, Yehoshoa,Milstein, David
supporting information, p. 20875 - 20882 (2020/12/23)
Selective oxidative deamination has long been considered to be an important but challenging transformation, although it is a common critical process in the metabolism of bioactive amino compounds. Most of the synthetic methods developed so far rely on the use of stoichiometric amounts of strong and toxic oxidants. Here we present a green and efficient method for oxidative deamination, using water as the oxidant, catalyzed by a ruthenium pincer complex. This unprecedented reaction protocol liberates hydrogen gas and avoids the use of sacrificial oxidants. A wide variety of primary amines are selectively transformed to carboxylates or ketones in good to high yields. It is noteworthy that mechanistic experiments and DFT calculations indicate that in addition to serving as the oxidant, water also plays an important role in assisting the hydrogen liberation steps involved in amine dehydrogenation.
New silver(I) pyridinecarboxylate complexes: Synthesis, characterization, and antimicrobial therapeutic potential
Vargova,Almasi,Hudecova,Titkova,Rostasova,Zelenak,Gyoeryova
, p. 1002 - 1021 (2014/05/20)
Silver(I) pyridinecarboxylates (AgPIC (1), AgNIC (2), [Ag(HDIPIC)]0. 75H2O (3), PIC = picolinate, NIC = nicotinate, HDIPIC = dipicolinate) were prepared by solvothermal syntheses and their characterization were completed by elemental, spectral, and thermal analyses. To assign the pyridinecarboxylate coordination mode in the complexes, detailed mid-infrared spectral data and Δ(as-s) comparisons were accomplished. In addition, silver(I) pyridinecarboxylate antimicrobial activities and stability by 1H NMR spectra were determined. Moreover, the spectral, thermal, and antimicrobial properties of silver(I) and previously prepared zinc(II) pyridinecarboxylates were compared and discussed. 2014
